A comparative study of once-daily versus twice-daily filgrastim administration for the mobilization and collection of CD34+ peripheral blood progenitor cells in normal donors

Paolo Anderlini; Michele Donato; Mary J. Lauppe; Yang O. Huh; Thomas G. Martin; Ka Wah Chan; Richard E. Champlin; Martin Körbling

doi:10.1046/j.1365-2141.2000.02083.x

A comparative study of once-daily versus twice-daily filgrastim administration for the mobilization and collection of CD34⁺ peripheral blood progenitor cells in normal donors

Paolo Anderlini
, Michele Donato
, Mary J. Lauppe
, Yang O. Huh
, Thomas G. Martin
, Ka Wah Chan
, Richard E. Champlin
, Martin Körbling

School of Medicine

University of Texas MD Anderson Cancer Center

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Eighty-one first-time normal donors underwent leukapheresis for peripheral blood progenitor cell (PBPC) collection after mobilization with filgrastim administered either twice-daily (6 μg/kg every 12 h: n = 40) or once-daily (12 μg/kg: n = 41) subcutaneously for 3 d. The groups were similar for age, donor blood volume and target CD34⁺ cell dose to be collected (≤ 4 x 10⁶ CD34⁺ cells/kg recipient). There was no statistically significant difference in the apheresis yield of CD34⁺ PBPCs (x 10⁶) per kg recipient weight (5·6 ± 3·3 vs. 5·6 ± 4·3: P = 0·94) and per litre of blood processed (30± 17·2 vs. 30·4 ± 19·5: P = 0·92).

Original language	English
Pages (from-to)	770-772
Number of pages	3
Journal	British Journal of Haematology
Volume	109
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.2000.02083.x
State	Published - 2000

Keywords

Filgrastim
Granulocyte colony- stimulating factor
Leukapheresis
Normal donors
Peripheral blood progenitor cell mobilization

Access to Document

10.1046/j.1365-2141.2000.02083.x

Cite this

Anderlini, P., Donato, M., Lauppe, M. J., Huh, Y. O., Martin, T. G., Chan, K. W., Champlin, R. E., & Körbling, M. (2000). A comparative study of once-daily versus twice-daily filgrastim administration for the mobilization and collection of CD34⁺ peripheral blood progenitor cells in normal donors. British Journal of Haematology, 109(4), 770-772. https://doi.org/10.1046/j.1365-2141.2000.02083.x

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title = "A comparative study of once-daily versus twice-daily filgrastim administration for the mobilization and collection of CD34+ peripheral blood progenitor cells in normal donors",

abstract = "Eighty-one first-time normal donors underwent leukapheresis for peripheral blood progenitor cell (PBPC) collection after mobilization with filgrastim administered either twice-daily (6 μg/kg every 12 h: n = 40) or once-daily (12 μg/kg: n = 41) subcutaneously for 3 d. The groups were similar for age, donor blood volume and target CD34+ cell dose to be collected (≤ 4 x 106 CD34+ cells/kg recipient). There was no statistically significant difference in the apheresis yield of CD34+ PBPCs (x 106) per kg recipient weight (5·6 ± 3·3 vs. 5·6 ± 4·3: P = 0·94) and per litre of blood processed (30± 17·2 vs. 30·4 ± 19·5: P = 0·92).",

keywords = "Filgrastim, Granulocyte colony- stimulating factor, Leukapheresis, Normal donors, Peripheral blood progenitor cell mobilization",

author = "Paolo Anderlini and Michele Donato and Lauppe, \{Mary J.\} and Huh, \{Yang O.\} and Martin, \{Thomas G.\} and Chan, \{Ka Wah\} and Champlin, \{Richard E.\} and Martin K{\"o}rbling",

year = "2000",

doi = "10.1046/j.1365-2141.2000.02083.x",

language = "English",

volume = "109",

pages = "770--772",

journal = "British Journal of Haematology",

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Anderlini, P, Donato, M, Lauppe, MJ, Huh, YO, Martin, TG, Chan, KW, Champlin, RE & Körbling, M 2000, 'A comparative study of once-daily versus twice-daily filgrastim administration for the mobilization and collection of CD34⁺ peripheral blood progenitor cells in normal donors', British Journal of Haematology, vol. 109, no. 4, pp. 770-772. https://doi.org/10.1046/j.1365-2141.2000.02083.x

A comparative study of once-daily versus twice-daily filgrastim administration for the mobilization and collection of CD34⁺ peripheral blood progenitor cells in normal donors. / Anderlini, Paolo; Donato, Michele; Lauppe, Mary J. et al.
In: British Journal of Haematology, Vol. 109, No. 4, 2000, p. 770-772.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A comparative study of once-daily versus twice-daily filgrastim administration for the mobilization and collection of CD34+ peripheral blood progenitor cells in normal donors

AU - Anderlini, Paolo

AU - Donato, Michele

AU - Lauppe, Mary J.

AU - Huh, Yang O.

AU - Martin, Thomas G.

AU - Chan, Ka Wah

AU - Champlin, Richard E.

AU - Körbling, Martin

PY - 2000

Y1 - 2000

N2 - Eighty-one first-time normal donors underwent leukapheresis for peripheral blood progenitor cell (PBPC) collection after mobilization with filgrastim administered either twice-daily (6 μg/kg every 12 h: n = 40) or once-daily (12 μg/kg: n = 41) subcutaneously for 3 d. The groups were similar for age, donor blood volume and target CD34+ cell dose to be collected (≤ 4 x 106 CD34+ cells/kg recipient). There was no statistically significant difference in the apheresis yield of CD34+ PBPCs (x 106) per kg recipient weight (5·6 ± 3·3 vs. 5·6 ± 4·3: P = 0·94) and per litre of blood processed (30± 17·2 vs. 30·4 ± 19·5: P = 0·92).

AB - Eighty-one first-time normal donors underwent leukapheresis for peripheral blood progenitor cell (PBPC) collection after mobilization with filgrastim administered either twice-daily (6 μg/kg every 12 h: n = 40) or once-daily (12 μg/kg: n = 41) subcutaneously for 3 d. The groups were similar for age, donor blood volume and target CD34+ cell dose to be collected (≤ 4 x 106 CD34+ cells/kg recipient). There was no statistically significant difference in the apheresis yield of CD34+ PBPCs (x 106) per kg recipient weight (5·6 ± 3·3 vs. 5·6 ± 4·3: P = 0·94) and per litre of blood processed (30± 17·2 vs. 30·4 ± 19·5: P = 0·92).

KW - Filgrastim

KW - Granulocyte colony- stimulating factor

KW - Leukapheresis

KW - Normal donors

KW - Peripheral blood progenitor cell mobilization

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U2 - 10.1046/j.1365-2141.2000.02083.x

DO - 10.1046/j.1365-2141.2000.02083.x

M3 - Article

C2 - 10929027

AN - SCOPUS:0033867087

SN - 0007-1048

VL - 109

SP - 770

EP - 772

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

A comparative study of once-daily versus twice-daily filgrastim administration for the mobilization and collection of CD34⁺ peripheral blood progenitor cells in normal donors

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Keywords

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