A phase I trial: Dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection

Gordon L. Phillips; Steven H. Bernstein; Jane L. Liesveld; Camille N. Abboud; Michael W. Becker; Louis S. Constine; J. J. Ifthikharuddin; John E. Loughner; Laurie A. Milner; David H. Vesole; Jonathan W. Friedberg

doi:10.1016/j.bbmt.2010.11.003

A phase I trial: Dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection

Gordon L. Phillips
, Steven H. Bernstein
, Jane L. Liesveld
, Camille N. Abboud
, Michael W. Becker
, Louis S. Constine
, J. J. Ifthikharuddin
, John E. Loughner
, Laurie A. Milner
, David H. Vesole
, Jonathan W. Friedberg

School of Medicine

University of Rochester
Washington University St. Louis

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

With the eventual goal of reducing relapse and thus improving overall survival in selected lymphoma patients, a Phase I study was performed using the cytoprotectant amifostine to permit safe dose-augmentation of melphalan in the carmustine (BCNU), etoposide, cytarabine (arabinosylcytosine), and melphalan (BEAM) regimen before autologous hematopoietic stem cell transplantation. Between 30 July 2003 and 25 November 2008, a total of 32 lymphoma patients were entered, of which 28 were evaluable. We found the melphalan dose in BEAM could be safely escalated to at least 260 mg/m², a substantial increase from the usual dose of 140 mg/m² in BEAM while the trial was terminated early due to poor accrual, no maximal tolerated dose or dose-limiting toxicity was found. A Phase II trial is planned.

Original language	English
Pages (from-to)	1033-1042
Number of pages	10
Journal	Biology of Blood and Marrow Transplantation
Volume	17
Issue number	7
DOIs	https://doi.org/10.1016/j.bbmt.2010.11.003
State	Published - Jul 2011

Keywords

Amifostine
Autologous stem cell
Melphalan
Phase I
Regimen-related toxicity

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10.1016/j.bbmt.2010.11.003

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Phillips, G. L., Bernstein, S. H., Liesveld, J. L., Abboud, C. N., Becker, M. W., Constine, L. S., Ifthikharuddin, J. J., Loughner, J. E., Milner, L. A., Vesole, D. H., & Friedberg, J. W. (2011). A phase I trial: Dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection. Biology of Blood and Marrow Transplantation, 17(7), 1033-1042. https://doi.org/10.1016/j.bbmt.2010.11.003

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title = "A phase I trial: Dose escalation of melphalan in the {"}BEAM{"} regimen using amifostine cytoprotection",

abstract = "With the eventual goal of reducing relapse and thus improving overall survival in selected lymphoma patients, a Phase I study was performed using the cytoprotectant amifostine to permit safe dose-augmentation of melphalan in the carmustine (BCNU), etoposide, cytarabine (arabinosylcytosine), and melphalan (BEAM) regimen before autologous hematopoietic stem cell transplantation. Between 30 July 2003 and 25 November 2008, a total of 32 lymphoma patients were entered, of which 28 were evaluable. We found the melphalan dose in BEAM could be safely escalated to at least 260 mg/m2, a substantial increase from the usual dose of 140 mg/m2 in BEAM while the trial was terminated early due to poor accrual, no maximal tolerated dose or dose-limiting toxicity was found. A Phase II trial is planned.",

keywords = "Amifostine, Autologous stem cell, Melphalan, Phase I, Regimen-related toxicity",

author = "Phillips, \{Gordon L.\} and Bernstein, \{Steven H.\} and Liesveld, \{Jane L.\} and Abboud, \{Camille N.\} and Becker, \{Michael W.\} and Constine, \{Louis S.\} and Ifthikharuddin, \{J. J.\} and Loughner, \{John E.\} and Milner, \{Laurie A.\} and Vesole, \{David H.\} and Friedberg, \{Jonathan W.\}",

year = "2011",

month = jul,

doi = "10.1016/j.bbmt.2010.11.003",

language = "English",

volume = "17",

pages = "1033--1042",

journal = "Biology of Blood and Marrow Transplantation",

issn = "1083-8791",

publisher = "Elsevier Inc.",

number = "7",

}

Phillips, GL, Bernstein, SH, Liesveld, JL, Abboud, CN, Becker, MW, Constine, LS, Ifthikharuddin, JJ, Loughner, JE, Milner, LA, Vesole, DH & Friedberg, JW 2011, 'A phase I trial: Dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection', Biology of Blood and Marrow Transplantation, vol. 17, no. 7, pp. 1033-1042. https://doi.org/10.1016/j.bbmt.2010.11.003

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AU - Phillips, Gordon L.

AU - Bernstein, Steven H.

AU - Liesveld, Jane L.

AU - Abboud, Camille N.

AU - Becker, Michael W.

AU - Constine, Louis S.

AU - Ifthikharuddin, J. J.

AU - Loughner, John E.

AU - Milner, Laurie A.

AU - Vesole, David H.

AU - Friedberg, Jonathan W.

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AB - With the eventual goal of reducing relapse and thus improving overall survival in selected lymphoma patients, a Phase I study was performed using the cytoprotectant amifostine to permit safe dose-augmentation of melphalan in the carmustine (BCNU), etoposide, cytarabine (arabinosylcytosine), and melphalan (BEAM) regimen before autologous hematopoietic stem cell transplantation. Between 30 July 2003 and 25 November 2008, a total of 32 lymphoma patients were entered, of which 28 were evaluable. We found the melphalan dose in BEAM could be safely escalated to at least 260 mg/m2, a substantial increase from the usual dose of 140 mg/m2 in BEAM while the trial was terminated early due to poor accrual, no maximal tolerated dose or dose-limiting toxicity was found. A Phase II trial is planned.

KW - Amifostine

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KW - Phase I

KW - Regimen-related toxicity

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JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 7

ER -

A phase I trial: Dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection

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Keywords

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