Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man

Amanda M. Holland; Johannes L. Zakrzewski; Gabrielle L. Goldberg; Arnab Ghosh; Marcel R.M. Van Den Brink

doi:10.1007/s00281-008-0138-z

Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man

Amanda M. Holland
, Johannes L. Zakrzewski
, Gabrielle L. Goldberg
, Arnab Ghosh
, Marcel R.M. Van Den Brink

Center for Discovery and Innovation

Memorial Sloan-Kettering Cancer Center
Cornell University

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Hematopoietic stem cell transplantation is a curative therapy for hematological malignancies. T cell deficiency following transplantation is a major cause of morbidity and mortality. In this review, we discuss adoptive transfer of committed precursor cells to enhance T cell reconstitution and improve overall prognosis after transplantation.

Original language	English
Pages (from-to)	479-487
Number of pages	9
Journal	Seminars in Immunopathology
Volume	30
Issue number	4
DOIs	https://doi.org/10.1007/s00281-008-0138-z
State	Published - Dec 2008

Keywords

Adoptive immunotherapy
Bone marrow transplantation
Immune reconstitution
T cell

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10.1007/s00281-008-0138-z

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title = "Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man",

abstract = "Hematopoietic stem cell transplantation is a curative therapy for hematological malignancies. T cell deficiency following transplantation is a major cause of morbidity and mortality. In this review, we discuss adoptive transfer of committed precursor cells to enhance T cell reconstitution and improve overall prognosis after transplantation.",

keywords = "Adoptive immunotherapy, Bone marrow transplantation, Immune reconstitution, T cell",

author = "Holland, \{Amanda M.\} and Zakrzewski, \{Johannes L.\} and Goldberg, \{Gabrielle L.\} and Arnab Ghosh and \{Van Den Brink\}, \{Marcel R.M.\}",

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T1 - Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man

AU - Holland, Amanda M.

AU - Zakrzewski, Johannes L.

AU - Goldberg, Gabrielle L.

AU - Ghosh, Arnab

AU - Van Den Brink, Marcel R.M.

PY - 2008/12

Y1 - 2008/12

N2 - Hematopoietic stem cell transplantation is a curative therapy for hematological malignancies. T cell deficiency following transplantation is a major cause of morbidity and mortality. In this review, we discuss adoptive transfer of committed precursor cells to enhance T cell reconstitution and improve overall prognosis after transplantation.

AB - Hematopoietic stem cell transplantation is a curative therapy for hematological malignancies. T cell deficiency following transplantation is a major cause of morbidity and mortality. In this review, we discuss adoptive transfer of committed precursor cells to enhance T cell reconstitution and improve overall prognosis after transplantation.

KW - Adoptive immunotherapy

KW - Bone marrow transplantation

KW - Immune reconstitution

KW - T cell

UR - https://www.scopus.com/pages/publications/57249088903

U2 - 10.1007/s00281-008-0138-z

DO - 10.1007/s00281-008-0138-z

M3 - Review article

C2 - 19015856

AN - SCOPUS:57249088903

SN - 1863-2297

VL - 30

SP - 479

EP - 487

JO - Seminars in Immunopathology

JF - Seminars in Immunopathology

IS - 4

ER -

Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man

Abstract

Keywords

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