Antibodies to GM1 and Gal(β1-3)GalNAc at the nodes of Ranvier in human and experimental autoimmune neuropathy

Florian P. Thomas

doi:10.1002/(SICI)1097-0029(19960815)34:6<536::AID-JEMT5>3.0.CO;2-H

Antibodies to GM1 and Gal(β1-3)GalNAc at the nodes of Ranvier in human and experimental autoimmune neuropathy

Florian P. Thomas

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Autoantibodies to Gal(β1-3)GalNAc epitopes on glycolipids and glycoproteins are associated with motor neuron disease and motor or sensorimotor neuropathy. These epitopes are ubiquitously distributed on cell surfaces. In the nervous system they are present on axons and myelin, specifically also at the nodes of Ranvier. Binding of GM 1 antibodies to the nodal area may contribute to disease development in some of these conditions.

Original language	English
Pages (from-to)	536-543
Number of pages	8
Journal	Microscopy Research and Technique
Volume	34
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1097-0029(19960815)34:6<536::AID-JEMT5>3.0.CO;2-H
State	Published - 15 Aug 1996

Keywords

Autoantibodies
Campylobacter
Gangliosides
Glycoproteins
GM1
Neuropathy
Nodes of Ranvier

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10.1002/(SICI)1097-0029(19960815)34:6<536::AID-JEMT5>3.0.CO;2-H

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title = "Antibodies to GM1 and Gal(β1-3)GalNAc at the nodes of Ranvier in human and experimental autoimmune neuropathy",

abstract = "Autoantibodies to Gal(β1-3)GalNAc epitopes on glycolipids and glycoproteins are associated with motor neuron disease and motor or sensorimotor neuropathy. These epitopes are ubiquitously distributed on cell surfaces. In the nervous system they are present on axons and myelin, specifically also at the nodes of Ranvier. Binding of GM 1 antibodies to the nodal area may contribute to disease development in some of these conditions.",

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T1 - Antibodies to GM1 and Gal(β1-3)GalNAc at the nodes of Ranvier in human and experimental autoimmune neuropathy

AU - Thomas, Florian P.

PY - 1996/8/15

Y1 - 1996/8/15

N2 - Autoantibodies to Gal(β1-3)GalNAc epitopes on glycolipids and glycoproteins are associated with motor neuron disease and motor or sensorimotor neuropathy. These epitopes are ubiquitously distributed on cell surfaces. In the nervous system they are present on axons and myelin, specifically also at the nodes of Ranvier. Binding of GM 1 antibodies to the nodal area may contribute to disease development in some of these conditions.

AB - Autoantibodies to Gal(β1-3)GalNAc epitopes on glycolipids and glycoproteins are associated with motor neuron disease and motor or sensorimotor neuropathy. These epitopes are ubiquitously distributed on cell surfaces. In the nervous system they are present on axons and myelin, specifically also at the nodes of Ranvier. Binding of GM 1 antibodies to the nodal area may contribute to disease development in some of these conditions.

KW - Autoantibodies

KW - Campylobacter

KW - Gangliosides

KW - Glycoproteins

KW - GM1

KW - Neuropathy

KW - Nodes of Ranvier

UR - https://www.scopus.com/pages/publications/0029781421

U2 - 10.1002/(SICI)1097-0029(19960815)34:6<536::AID-JEMT5>3.0.CO;2-H

DO - 10.1002/(SICI)1097-0029(19960815)34:6<536::AID-JEMT5>3.0.CO;2-H

M3 - Article

C2 - 8842022

AN - SCOPUS:0029781421

SN - 1059-910X

VL - 34

SP - 536

EP - 543

JO - Microscopy Research and Technique

JF - Microscopy Research and Technique

IS - 6

ER -

Antibodies to GM1 and Gal(β1-3)GalNAc at the nodes of Ranvier in human and experimental autoimmune neuropathy

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Keywords

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