Carbapenemase-producing Klebsiella pneumoniae: Molecular and genetic decoding

Liang Chen; Barun Mathema; Kalyan D. Chavda; Frank R. DeLeo; Robert A. Bonomo; Barry N. Kreiswirth

doi:10.1016/j.tim.2014.09.003

Carbapenemase-producing Klebsiella pneumoniae: Molecular and genetic decoding

Liang Chen
, Barun Mathema
, Kalyan D. Chavda
, Frank R. DeLeo
, Robert A. Bonomo
, Barry N. Kreiswirth

Rutgers - The State University of New Jersey, Newark
Columbia University
National Institutes of Health
Louis Stokes Cleveland Department of Veterans Affairs Medical Center
Case Western Reserve University

Research output: Contribution to journal › Review article › peer-review

506 Scopus citations

Abstract

Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of bla_KPC involves both horizontal transfer of bla_KPC genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.

Original language	English
Pages (from-to)	686-696
Number of pages	11
Journal	Trends in Microbiology
Volume	22
Issue number	12
DOIs	https://doi.org/10.1016/j.tim.2014.09.003
State	Published - 1 Dec 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carbapenem-resistant
Klebsiella pneumoniae carbapenemase
ST258

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10.1016/j.tim.2014.09.003

Cite this

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title = "Carbapenemase-producing Klebsiella pneumoniae: Molecular and genetic decoding",

abstract = "Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of blaKPC involves both horizontal transfer of blaKPC genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.",

keywords = "Carbapenem-resistant, Klebsiella pneumoniae carbapenemase, ST258",

author = "Liang Chen and Barun Mathema and Chavda, \{Kalyan D.\} and DeLeo, \{Frank R.\} and Bonomo, \{Robert A.\} and Kreiswirth, \{Barry N.\}",

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year = "2014",

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doi = "10.1016/j.tim.2014.09.003",

language = "English",

volume = "22",

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TY - JOUR

T1 - Carbapenemase-producing Klebsiella pneumoniae

T2 - Molecular and genetic decoding

AU - Chen, Liang

AU - Mathema, Barun

AU - Chavda, Kalyan D.

AU - DeLeo, Frank R.

AU - Bonomo, Robert A.

AU - Kreiswirth, Barry N.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of blaKPC involves both horizontal transfer of blaKPC genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.

AB - Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of blaKPC involves both horizontal transfer of blaKPC genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.

KW - Carbapenem-resistant

KW - Klebsiella pneumoniae carbapenemase

KW - ST258

UR - https://www.scopus.com/pages/publications/84922749986

U2 - 10.1016/j.tim.2014.09.003

DO - 10.1016/j.tim.2014.09.003

M3 - Review article

C2 - 25304194

AN - SCOPUS:84922749986

SN - 0966-842X

VL - 22

SP - 686

EP - 696

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 12

ER -

Carbapenemase-producing Klebsiella pneumoniae: Molecular and genetic decoding

Abstract

UN SDGs

Keywords

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