Clinical failure of vancomycin in a dialysis patient with methicillin-susceptible vancomycin-heteroresistant S. aureus

Dahlene N. Fusco; Elizabeth L. Alexander; Scott A. Weisenberg; Jose R. Mediavilla; Barry N. Kreiswirth; Audrey N. Schuetz; Stephen G. Jenkins; Kyu Y. Rhee

doi:10.1016/j.diagmicrobio.2009.05.017

Clinical failure of vancomycin in a dialysis patient with methicillin-susceptible vancomycin-heteroresistant S. aureus

Dahlene N. Fusco
, Elizabeth L. Alexander
, Scott A. Weisenberg
, Jose R. Mediavilla
, Barry N. Kreiswirth
, Audrey N. Schuetz
, Stephen G. Jenkins
, Kyu Y. Rhee

Center for Discovery and Innovation

New York Presbyterian Hospital
Public Health Research Institute, New York
Cornell University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We report a case of recurrent Staphylococcus aureus bacteremia in a patient who failed vancomycin due to a vancomycin-heteroresistant strain lacking methicillin resistance. Although initial isolates were susceptible, isolates obtained after vancomycin chemotherapy were vancomycin heteroresistant. This case thus illustrates the clinical emergence of vancomycin heteroresistance.

Original language	English
Pages (from-to)	180-183
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	65
Issue number	2
DOIs	https://doi.org/10.1016/j.diagmicrobio.2009.05.017
State	Published - Oct 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Failure
Heteroresistance
Staphylococcus aureus
Vancomycin

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10.1016/j.diagmicrobio.2009.05.017

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Fusco, D. N., Alexander, E. L., Weisenberg, S. A., Mediavilla, J. R., Kreiswirth, B. N., Schuetz, A. N., Jenkins, S. G., & Rhee, K. Y. (2009). Clinical failure of vancomycin in a dialysis patient with methicillin-susceptible vancomycin-heteroresistant S. aureus. Diagnostic Microbiology and Infectious Disease, 65(2), 180-183. https://doi.org/10.1016/j.diagmicrobio.2009.05.017

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abstract = "We report a case of recurrent Staphylococcus aureus bacteremia in a patient who failed vancomycin due to a vancomycin-heteroresistant strain lacking methicillin resistance. Although initial isolates were susceptible, isolates obtained after vancomycin chemotherapy were vancomycin heteroresistant. This case thus illustrates the clinical emergence of vancomycin heteroresistance.",

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AU - Fusco, Dahlene N.

AU - Alexander, Elizabeth L.

AU - Weisenberg, Scott A.

AU - Mediavilla, Jose R.

AU - Kreiswirth, Barry N.

AU - Schuetz, Audrey N.

AU - Jenkins, Stephen G.

AU - Rhee, Kyu Y.

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KW - Heteroresistance

KW - Staphylococcus aureus

KW - Vancomycin

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ER -

Clinical failure of vancomycin in a dialysis patient with methicillin-susceptible vancomycin-heteroresistant S. aureus

Abstract

UN SDGs

Keywords

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