Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations

Soraya L. Moghazeh; Xi Pan; Taraq Arain; C. Kendall Stover; James M. Musser; Barry N. Kreiswirth

doi:10.1128/aac.40.11.2655

Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations

Soraya L. Moghazeh
, Xi Pan
, Taraq Arain
, C. Kendall Stover
, James M. Musser
, Barry N. Kreiswirth

Public Health Research Institute, New York
Baylor College of Medicine
Novartis

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

A collection of 24 rifampin-resistant clinical isolates of Mycobacterium tuberculosis with characterized RNA polymerase β-subunit (rpoB) gene mutations was tested against the antimycobacterial agents rifampin, rifapentine, and KRM-1648 to correlate levels of resistance with specific rpoB genotypes. The results indicate that KRM-1648 is more active in vitro than rifampin and rifapentine, and its ability to overcome rifampin resistance in strains with four different genetic alterations may prove to be useful in understanding structure-function relationships.

Original language	English
Pages (from-to)	2655-2657
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	40
Issue number	11
DOIs	https://doi.org/10.1128/aac.40.11.2655
State	Published - Nov 1996

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10.1128/aac.40.11.2655

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Moghazeh, S. L., Pan, X., Arain, T., Stover, C. K., Musser, J. M., & Kreiswirth, B. N. (1996). Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. Antimicrobial Agents and Chemotherapy, 40(11), 2655-2657. https://doi.org/10.1128/aac.40.11.2655

@article{0ceea887ee6c41469b80cb6ab1d44d2f,

title = "Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations",

abstract = "A collection of 24 rifampin-resistant clinical isolates of Mycobacterium tuberculosis with characterized RNA polymerase β-subunit (rpoB) gene mutations was tested against the antimycobacterial agents rifampin, rifapentine, and KRM-1648 to correlate levels of resistance with specific rpoB genotypes. The results indicate that KRM-1648 is more active in vitro than rifampin and rifapentine, and its ability to overcome rifampin resistance in strains with four different genetic alterations may prove to be useful in understanding structure-function relationships.",

author = "Moghazeh, \{Soraya L.\} and Xi Pan and Taraq Arain and Stover, \{C. Kendall\} and Musser, \{James M.\} and Kreiswirth, \{Barry N.\}",

year = "1996",

month = nov,

doi = "10.1128/aac.40.11.2655",

language = "English",

volume = "40",

pages = "2655--2657",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "11",

}

Moghazeh, SL, Pan, X, Arain, T, Stover, CK, Musser, JM & Kreiswirth, BN 1996, 'Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations', Antimicrobial Agents and Chemotherapy, vol. 40, no. 11, pp. 2655-2657. https://doi.org/10.1128/aac.40.11.2655

Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations. / Moghazeh, Soraya L.; Pan, Xi; Arain, Taraq et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 40, No. 11, 11.1996, p. 2655-2657.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations

AU - Moghazeh, Soraya L.

AU - Pan, Xi

AU - Arain, Taraq

AU - Stover, C. Kendall

AU - Musser, James M.

AU - Kreiswirth, Barry N.

PY - 1996/11

Y1 - 1996/11

N2 - A collection of 24 rifampin-resistant clinical isolates of Mycobacterium tuberculosis with characterized RNA polymerase β-subunit (rpoB) gene mutations was tested against the antimycobacterial agents rifampin, rifapentine, and KRM-1648 to correlate levels of resistance with specific rpoB genotypes. The results indicate that KRM-1648 is more active in vitro than rifampin and rifapentine, and its ability to overcome rifampin resistance in strains with four different genetic alterations may prove to be useful in understanding structure-function relationships.

AB - A collection of 24 rifampin-resistant clinical isolates of Mycobacterium tuberculosis with characterized RNA polymerase β-subunit (rpoB) gene mutations was tested against the antimycobacterial agents rifampin, rifapentine, and KRM-1648 to correlate levels of resistance with specific rpoB genotypes. The results indicate that KRM-1648 is more active in vitro than rifampin and rifapentine, and its ability to overcome rifampin resistance in strains with four different genetic alterations may prove to be useful in understanding structure-function relationships.

UR - https://www.scopus.com/pages/publications/0029861539

U2 - 10.1128/aac.40.11.2655

DO - 10.1128/aac.40.11.2655

M3 - Article

C2 - 8913484

AN - SCOPUS:0029861539

SN - 0066-4804

VL - 40

SP - 2655

EP - 2657

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations

Abstract

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