Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

Juan Luis Rodriguez-Tudela; Alicia Gomez-Lopez; Maiken C. Arendrup; Guillermo Garcia-Effron; David S. Perlin; Cornelia Lass-Flörl; Manuel Cuenca-Estrella

doi:10.1128/AAC.00597-10

Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

Juan Luis Rodriguez-Tudela
, Alicia Gomez-Lopez
, Maiken C. Arendrup
, Guillermo Garcia-Effron
, David S. Perlin
, Cornelia Lass-Flörl
, Manuel Cuenca-Estrella

Center for Discovery and Innovation

Instituto de Salud Carlos III
Statens Serum Institut
Universidad Nacional del Litoral
Public Health Research Institute, New York
Innsbruck Medical University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.

Original language	English
Pages (from-to)	3056-3057
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	54
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00597-10
State	Published - Jul 2010

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title = "Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose",

abstract = "According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2\% versus 0.2\%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9\%), showing that glucose does not interfere with susceptibility.",

author = "Rodriguez-Tudela, \{Juan Luis\} and Alicia Gomez-Lopez and Arendrup, \{Maiken C.\} and Guillermo Garcia-Effron and Perlin, \{David S.\} and Cornelia Lass-Fl{\"o}rl and Manuel Cuenca-Estrella",

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doi = "10.1128/AAC.00597-10",

language = "English",

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AU - Rodriguez-Tudela, Juan Luis

AU - Gomez-Lopez, Alicia

AU - Arendrup, Maiken C.

AU - Garcia-Effron, Guillermo

AU - Perlin, David S.

AU - Lass-Flörl, Cornelia

AU - Cuenca-Estrella, Manuel

PY - 2010/7

Y1 - 2010/7

N2 - According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.

AB - According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.

UR - https://www.scopus.com/pages/publications/77953754307

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

ER -

Comparison of caspofungin MICs by means of EUCAST method EDef 7.1 using two different concentrations of glucose

Abstract

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