Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1

Dinesh Raghu; Hai Hui Xue; Lisa A. Mielke

doi:10.1016/j.it.2019.10.006

Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1

Dinesh Raghu
, Hai Hui Xue
, Lisa A. Mielke

Center for Discovery and Innovation

La Trobe University
Olivia Newton-John Cancer Research Institute

Research output: Contribution to journal › Review article › peer-review

94 Scopus citations

Abstract

T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8⁺ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).

Original language	English
Pages (from-to)	1149-1162
Number of pages	14
Journal	Trends in Immunology
Volume	40
Issue number	12
DOIs	https://doi.org/10.1016/j.it.2019.10.006
State	Published - Dec 2019

Keywords

immunotherapy
innate lymphoid cell
stem cell-like memory
T cell
T cell factor-1
TCF-1
transcription factor

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10.1016/j.it.2019.10.006

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title = "Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1",

abstract = "T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).",

keywords = "immunotherapy, innate lymphoid cell, stem cell-like memory, T cell, T cell factor-1, TCF-1, transcription factor",

author = "Dinesh Raghu and Xue, \{Hai Hui\} and Mielke, \{Lisa A.\}",

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AU - Raghu, Dinesh

AU - Xue, Hai Hui

AU - Mielke, Lisa A.

PY - 2019/12

Y1 - 2019/12

N2 - T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).

AB - T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8+ T cells that may help to predict patient responses to immune checkpoint blockade (ICB).

KW - immunotherapy

KW - innate lymphoid cell

KW - stem cell-like memory

KW - T cell

KW - T cell factor-1

KW - TCF-1

KW - transcription factor

UR - https://www.scopus.com/pages/publications/85075438725

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DO - 10.1016/j.it.2019.10.006

M3 - Review article

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AN - SCOPUS:85075438725

SN - 1471-4906

VL - 40

SP - 1149

EP - 1162

JO - Trends in Immunology

JF - Trends in Immunology

IS - 12

ER -

Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1

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Keywords

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