Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China

Hua Yu; Fen Qu; Bin Shan; Bin Huang; Wei Jia; Cha Chen; Aiqing Li; Minhui Miao; Xin Zhang; Chunmei Bao; Yunmin Xu; Kalyan D. Chavda; Yi Wei Tang; Barry N. Kreiswirth; Hong Du; Liang Chen

doi:10.1128/AAC.00440-16

Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China

Hua Yu
, Fen Qu
, Bin Shan
, Bin Huang
, Wei Jia
, Cha Chen
, Aiqing Li
, Minhui Miao
, Xin Zhang
, Chunmei Bao
, Yunmin Xu
, Kalyan D. Chavda
, Yi Wei Tang
, Barry N. Kreiswirth
, Hong Du
, Liang Chen

Center for Discovery and Innovation

Sichuan Provincial People's Hospital
PLA No. 302 Hospital
Kunming Medical College
Sun Yat-Sen University
Ningxia Medical University
Traditional Chinese Medical Hospital of Guangdong
Soochow University
Public Health Research Institute, New York
Memorial Sloan-Kettering Cancer Center

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

Original language	English
Pages (from-to)	5033-5035
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00440-16
State	Published - Aug 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1128/AAC.00440-16

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Yu, H., Qu, F., Shan, B., Huang, B., Jia, W., Chen, C., Li, A., Miao, M., Zhang, X., Bao, C., Xu, Y., Chavda, K. D., Tang, Y. W., Kreiswirth, B. N., Du, H., & Chen, L. (2016). Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China. Antimicrobial Agents and Chemotherapy, 60(8), 5033-5035. https://doi.org/10.1128/AAC.00440-16

@article{15fe5cd2ec5e46ea9361a6ee6cf69a04,

title = "Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China",

abstract = "The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.",

author = "Hua Yu and Fen Qu and Bin Shan and Bin Huang and Wei Jia and Cha Chen and Aiqing Li and Minhui Miao and Xin Zhang and Chunmei Bao and Yunmin Xu and Chavda, \{Kalyan D.\} and Tang, \{Yi Wei\} and Kreiswirth, \{Barry N.\} and Hong Du and Liang Chen",

year = "2016",

month = aug,

doi = "10.1128/AAC.00440-16",

language = "English",

volume = "60",

pages = "5033--5035",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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}

Yu, H, Qu, F, Shan, B, Huang, B, Jia, W, Chen, C, Li, A, Miao, M, Zhang, X, Bao, C, Xu, Y, Chavda, KD, Tang, YW, Kreiswirth, BN, Du, H & Chen, L 2016, 'Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China', Antimicrobial Agents and Chemotherapy, vol. 60, no. 8, pp. 5033-5035. https://doi.org/10.1128/AAC.00440-16

TY - JOUR

T1 - Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China

AU - Yu, Hua

AU - Qu, Fen

AU - Shan, Bin

AU - Huang, Bin

AU - Jia, Wei

AU - Chen, Cha

AU - Li, Aiqing

AU - Miao, Minhui

AU - Zhang, Xin

AU - Bao, Chunmei

AU - Xu, Yunmin

AU - Chavda, Kalyan D.

AU - Tang, Yi Wei

AU - Kreiswirth, Barry N.

AU - Du, Hong

AU - Chen, Liang

PY - 2016/8

Y1 - 2016/8

N2 - The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

AB - The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.

UR - https://www.scopus.com/pages/publications/84979306871

U2 - 10.1128/AAC.00440-16

DO - 10.1128/AAC.00440-16

M3 - Article

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AN - SCOPUS:84979306871

SN - 0066-4804

VL - 60

SP - 5033

EP - 5035

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China

Abstract

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