Abstract
In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced inierleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.
| Original language | English |
|---|---|
| Pages (from-to) | 5511-5514 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 72 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2004 |
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SDG 3 Good Health and Well-being
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