Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

John E. Janik; John C. Morris; Stefania Pittaluga; Kristin McDonald; Mark Raffeld; Elaine S. Jaffe; Nicole Grant; Martin Gutierrez; Thomas A. Waldmann; Wyndham H. Wilson

doi:10.1182/blood-2003-11-3922

Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

John E. Janik
, John C. Morris
, Stefania Pittaluga
, Kristin McDonald
, Mark Raffeld
, Elaine S. Jaffe
, Nicole Grant
, Martin Gutierrez
, Thomas A. Waldmann
, Wyndham H. Wilson

School of Medicine

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Levels of serum soluble interleukin 2 receptor (sIL-2R) provide a reliable marker of disease activity in patients with hairy cell leukemia and adult T-cell leukemia/ lymphoma. The malignant cells in patients with anaplastic large cell lymphoma (ALCL) express CD30 and are usually positive for expression of CD25. We measured serum sIL-2R and soluble CD30 (sCD30) levels in patients with ALCL treated with EPOCH (etoposide, prednisone, Oncovin, Cytoxan, hydroxydaunorubicin) infusional chemotherapy. Serum sCD30 levels were elevated and decreased in response to therapy as previously reported. Serum sIL-2R levels were elevated in 7 of 9 patients with ALCL and decreased in response to treatment. Baseline serum sIL-2R levels varied but correlated well with serum sCD30 levels (r = 0.97). Patients positive for the anaplastic lymphoma kinase (ALK) gene showed elevated sIL-2R levels, whereas those negative for ALK had normal serum sIL-2R levels and their tumors lacked CD25 expression. Serum sIL-2R levels were elevated in both patients with recurrent disease.

Original language	English
Pages (from-to)	3355-3357
Number of pages	3
Journal	Blood
Volume	104
Issue number	10
DOIs	https://doi.org/10.1182/blood-2003-11-3922
State	Published - 15 Nov 2004

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@article{614603effbcc458aaea141628e1f7f38,

title = "Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma",

abstract = "Levels of serum soluble interleukin 2 receptor (sIL-2R) provide a reliable marker of disease activity in patients with hairy cell leukemia and adult T-cell leukemia/ lymphoma. The malignant cells in patients with anaplastic large cell lymphoma (ALCL) express CD30 and are usually positive for expression of CD25. We measured serum sIL-2R and soluble CD30 (sCD30) levels in patients with ALCL treated with EPOCH (etoposide, prednisone, Oncovin, Cytoxan, hydroxydaunorubicin) infusional chemotherapy. Serum sCD30 levels were elevated and decreased in response to therapy as previously reported. Serum sIL-2R levels were elevated in 7 of 9 patients with ALCL and decreased in response to treatment. Baseline serum sIL-2R levels varied but correlated well with serum sCD30 levels (r = 0.97). Patients positive for the anaplastic lymphoma kinase (ALK) gene showed elevated sIL-2R levels, whereas those negative for ALK had normal serum sIL-2R levels and their tumors lacked CD25 expression. Serum sIL-2R levels were elevated in both patients with recurrent disease.",

author = "Janik, \{John E.\} and Morris, \{John C.\} and Stefania Pittaluga and Kristin McDonald and Mark Raffeld and Jaffe, \{Elaine S.\} and Nicole Grant and Martin Gutierrez and Waldmann, \{Thomas A.\} and Wilson, \{Wyndham H.\}",

year = "2004",

month = nov,

day = "15",

doi = "10.1182/blood-2003-11-3922",

language = "English",

volume = "104",

pages = "3355--3357",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier B.V.",

number = "10",

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T1 - Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

AU - Janik, John E.

AU - Morris, John C.

AU - Pittaluga, Stefania

AU - McDonald, Kristin

AU - Raffeld, Mark

AU - Jaffe, Elaine S.

AU - Grant, Nicole

AU - Gutierrez, Martin

AU - Waldmann, Thomas A.

AU - Wilson, Wyndham H.

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Levels of serum soluble interleukin 2 receptor (sIL-2R) provide a reliable marker of disease activity in patients with hairy cell leukemia and adult T-cell leukemia/ lymphoma. The malignant cells in patients with anaplastic large cell lymphoma (ALCL) express CD30 and are usually positive for expression of CD25. We measured serum sIL-2R and soluble CD30 (sCD30) levels in patients with ALCL treated with EPOCH (etoposide, prednisone, Oncovin, Cytoxan, hydroxydaunorubicin) infusional chemotherapy. Serum sCD30 levels were elevated and decreased in response to therapy as previously reported. Serum sIL-2R levels were elevated in 7 of 9 patients with ALCL and decreased in response to treatment. Baseline serum sIL-2R levels varied but correlated well with serum sCD30 levels (r = 0.97). Patients positive for the anaplastic lymphoma kinase (ALK) gene showed elevated sIL-2R levels, whereas those negative for ALK had normal serum sIL-2R levels and their tumors lacked CD25 expression. Serum sIL-2R levels were elevated in both patients with recurrent disease.

AB - Levels of serum soluble interleukin 2 receptor (sIL-2R) provide a reliable marker of disease activity in patients with hairy cell leukemia and adult T-cell leukemia/ lymphoma. The malignant cells in patients with anaplastic large cell lymphoma (ALCL) express CD30 and are usually positive for expression of CD25. We measured serum sIL-2R and soluble CD30 (sCD30) levels in patients with ALCL treated with EPOCH (etoposide, prednisone, Oncovin, Cytoxan, hydroxydaunorubicin) infusional chemotherapy. Serum sCD30 levels were elevated and decreased in response to therapy as previously reported. Serum sIL-2R levels were elevated in 7 of 9 patients with ALCL and decreased in response to treatment. Baseline serum sIL-2R levels varied but correlated well with serum sCD30 levels (r = 0.97). Patients positive for the anaplastic lymphoma kinase (ALK) gene showed elevated sIL-2R levels, whereas those negative for ALK had normal serum sIL-2R levels and their tumors lacked CD25 expression. Serum sIL-2R levels were elevated in both patients with recurrent disease.

UR - https://www.scopus.com/pages/publications/8644228628

U2 - 10.1182/blood-2003-11-3922

DO - 10.1182/blood-2003-11-3922

M3 - Article

C2 - 15205267

AN - SCOPUS:8644228628

SN - 0006-4971

VL - 104

SP - 3355

EP - 3357

JO - Blood

JF - Blood

IS - 10

ER -

Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

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