Emergence of resistance to colistin during the treatment of bloodstream infection caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae

Antibacterial Resistance Leadership Group

doi:10.1093/ofid/ofy054

Emergence of resistance to colistin during the treatment of bloodstream infection caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae

Antibacterial Resistance Leadership Group

Center for Discovery and Innovation

Case Western Reserve University
Department of Veterans Affairs
Public Health Research Institute, New York
University of North Carolina at Chapel Hill

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofy054
State	Published - 1 Apr 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carbapenemase
Colistin resistance
Klebsiella pneumoniae

Access to Document

10.1093/ofid/ofy054

Cite this

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title = "Emergence of resistance to colistin during the treatment of bloodstream infection caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae",

abstract = "We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.",

keywords = "Carbapenemase, Colistin resistance, Klebsiella pneumoniae",

author = "\{Antibacterial Resistance Leadership Group\} and Anubhav Kanwar and Marshall, \{Steven H.\} and Federico Perez and Myreen Tomas and Jacobs, \{Michael R.\} and Hujer, \{Andrea M.\} and \{Nicholas Domitrovic\}, T. and Rudin, \{Susan D.\} and Rojas, \{Laura J.\} and Kreiswirth, \{Barry N.\} and Liang Chen and Miguel Quinones-Mateu and \{Van Duin\}, David and Bonomo, \{Robert A.\}",

note = "Publisher Copyright: {\textcopyright} Published by Oxford University Press on behalf of Infectious Diseases Society of America 2018.",

year = "2018",

month = apr,

day = "1",

doi = "10.1093/ofid/ofy054",

language = "English",

volume = "5",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Emergence of resistance to colistin during the treatment of bloodstream infection caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae

AU - Antibacterial Resistance Leadership Group

AU - Kanwar, Anubhav

AU - Marshall, Steven H.

AU - Perez, Federico

AU - Tomas, Myreen

AU - Jacobs, Michael R.

AU - Hujer, Andrea M.

AU - Nicholas Domitrovic, T.

AU - Rudin, Susan D.

AU - Rojas, Laura J.

AU - Kreiswirth, Barry N.

AU - Chen, Liang

AU - Quinones-Mateu, Miguel

AU - Van Duin, David

AU - Bonomo, Robert A.

N1 - Publisher Copyright: © Published by Oxford University Press on behalf of Infectious Diseases Society of America 2018.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.

AB - We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.

KW - Carbapenemase

KW - Colistin resistance

KW - Klebsiella pneumoniae

UR - https://www.scopus.com/pages/publications/85067136480

U2 - 10.1093/ofid/ofy054

DO - 10.1093/ofid/ofy054

M3 - Article

AN - SCOPUS:85067136480

SN - 2328-8957

VL - 5

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 4

ER -

Emergence of resistance to colistin during the treatment of bloodstream infection caused by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae

Abstract

UN SDGs

Keywords

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