Epetraborole is active against mycobacterium abscessus

Uday S. Ganapathy; Martin Gengenbacher; Thomas Dick

doi:10.1128/AAC.01156-21

Epetraborole is active against mycobacterium abscessus

Center for Discovery and Innovation

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole epetraborole, a clinical candidate developed for Gram-negative infections, is also active against M. abscessus in vitro and in a mouse model of infection. This expands the repertoire of advanced lead compounds for the discovery of a benzoxaborole-based candidate to treat M. abscessus lung disease.

Original language	English
Article number	e01156-21
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	10
DOIs	https://doi.org/10.1128/AAC.01156-21
State	Published - Oct 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Benzoxaborole
Epetraborole
Mycobacterium abscessus
NTM
Nontuberculous mycobacteria

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10.1128/AAC.01156-21

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title = "Epetraborole is active against mycobacterium abscessus",

abstract = "Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole epetraborole, a clinical candidate developed for Gram-negative infections, is also active against M. abscessus in vitro and in a mouse model of infection. This expands the repertoire of advanced lead compounds for the discovery of a benzoxaborole-based candidate to treat M. abscessus lung disease.",

keywords = "Benzoxaborole, Epetraborole, Mycobacterium abscessus, NTM, Nontuberculous mycobacteria",

author = "Ganapathy, \{Uday S.\} and Martin Gengenbacher and Thomas Dick",

note = "Publisher Copyright: {\textcopyright} 2021 Ganapathy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",

year = "2021",

month = oct,

doi = "10.1128/AAC.01156-21",

language = "English",

volume = "65",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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T1 - Epetraborole is active against mycobacterium abscessus

AU - Ganapathy, Uday S.

AU - Gengenbacher, Martin

AU - Dick, Thomas

PY - 2021/10

Y1 - 2021/10

N2 - Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole epetraborole, a clinical candidate developed for Gram-negative infections, is also active against M. abscessus in vitro and in a mouse model of infection. This expands the repertoire of advanced lead compounds for the discovery of a benzoxaborole-based candidate to treat M. abscessus lung disease.

AB - Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole epetraborole, a clinical candidate developed for Gram-negative infections, is also active against M. abscessus in vitro and in a mouse model of infection. This expands the repertoire of advanced lead compounds for the discovery of a benzoxaborole-based candidate to treat M. abscessus lung disease.

KW - Benzoxaborole

KW - Epetraborole

KW - Mycobacterium abscessus

KW - NTM

KW - Nontuberculous mycobacteria

UR - https://www.scopus.com/pages/publications/85115195042

U2 - 10.1128/AAC.01156-21

DO - 10.1128/AAC.01156-21

M3 - Article

C2 - 34280020

AN - SCOPUS:85115195042

SN - 0066-4804

VL - 65

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

M1 - e01156-21

ER -

Epetraborole is active against mycobacterium abscessus

Abstract

UN SDGs

Keywords

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