Abstract
Costimulatory molecule B7-H4, a member of the B7 family, negatively regulates the immune response of T cells through inhibiting their proliferation, cytokine production and cell cycle. The overexpression of B7-H4 plays an important role in initiation, progression and regression of tumors by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis. B7-H4 expression in malignant tumors is useful for clinical diagnosis, and may provide a novel molecular target for cancer treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 700-705 |
| Number of pages | 6 |
| Journal | Onkologie |
| Volume | 35 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2012 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- B7-H4
- Costimulatory signal
- Immune invasion
- Malignant tumor
- Molecular target
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