First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine

Liang Chen; Nahed Al Laham; Kalyan D. Chavda; Jose R. Mediavilla; Michael R. Jacobs; Robert A. Bonomo; Barry N. Kreiswirth

doi:10.1128/AAC.00565-15

First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine

Liang Chen
, Nahed Al Laham
, Kalyan D. Chavda
, Jose R. Mediavilla
, Michael R. Jacobs
, Robert A. Bonomo
, Barry N. Kreiswirth

Center for Discovery and Innovation

Public Health Research Institute, New York
Al-Azhar University of Gaza
Case Western Reserve University
Department of Veterans Affairs

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the bla_OXA-48-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene bla_OXA-48, extended spectrum β-lactamase gene bla_CTX-M-14, and aminoglycoside resistance genes strA, strB, and aph(3′)-VIb.

Original language	English
Pages (from-to)	4305-4307
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00565-15
State	Published - 1 Jul 2015

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SDG 3 Good Health and Well-being

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10.1128/AAC.00565-15

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title = "First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine",

abstract = "We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the blaOXA-48-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene blaOXA-48, extended spectrum β-lactamase gene blaCTX-M-14, and aminoglycoside resistance genes strA, strB, and aph(3′)-VIb.",

author = "Liang Chen and \{Al Laham\}, Nahed and Chavda, \{Kalyan D.\} and Mediavilla, \{Jose R.\} and Jacobs, \{Michael R.\} and Bonomo, \{Robert A.\} and Kreiswirth, \{Barry N.\}",

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doi = "10.1128/AAC.00565-15",

language = "English",

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AU - Chen, Liang

AU - Al Laham, Nahed

AU - Chavda, Kalyan D.

AU - Mediavilla, Jose R.

AU - Jacobs, Michael R.

AU - Bonomo, Robert A.

AU - Kreiswirth, Barry N.

PY - 2015/7/1

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N2 - We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the blaOXA-48-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene blaOXA-48, extended spectrum β-lactamase gene blaCTX-M-14, and aminoglycoside resistance genes strA, strB, and aph(3′)-VIb.

AB - We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the blaOXA-48-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene blaOXA-48, extended spectrum β-lactamase gene blaCTX-M-14, and aminoglycoside resistance genes strA, strB, and aph(3′)-VIb.

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SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

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ER -

First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine

Abstract

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