Genomic characterization of Enterobacter cloacae isolates from China that coproduce KPC-3 and NDM-1 carbapenemases

Hong Du; Liang Chen; Kalyan D. Chavda; Ruchi Pandey; Haifang Zhang; Xiaofang Xie; Yi Wei Tang; Barry N. Kreiswirth

doi:10.1128/AAC.03053-15

Genomic characterization of Enterobacter cloacae isolates from China that coproduce KPC-3 and NDM-1 carbapenemases

Hong Du
, Liang Chen
, Kalyan D. Chavda
, Ruchi Pandey
, Haifang Zhang
, Xiaofang Xie
, Yi Wei Tang
, Barry N. Kreiswirth

Center for Discovery and Innovation

Soochow University
Rutgers - The State University of New Jersey, Newark
Memorial Sloan-Kettering Cancer Center

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The bla_NDM-1-harboring plasmids carry IncA/C₂ and IncR replicons, showing a mosaic plasmid structure, and the bla_NDM-1 is harbored on a novel class I integron-like element. bla_KPC-3 is located on a Tn3-Δbla_TEM-1-bla_KPC-3-ΔTn1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.

Original language	English
Pages (from-to)	2519-2523
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	4
DOIs	https://doi.org/10.1128/AAC.03053-15
State	Published - Apr 2016

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title = "Genomic characterization of Enterobacter cloacae isolates from China that coproduce KPC-3 and NDM-1 carbapenemases",

abstract = "Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The blaNDM-1-harboring plasmids carry IncA/C2 and IncR replicons, showing a mosaic plasmid structure, and the blaNDM-1 is harbored on a novel class I integron-like element. blaKPC-3 is located on a Tn3-ΔblaTEM-1-blaKPC-3-ΔTn1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.",

author = "Hong Du and Liang Chen and Chavda, \{Kalyan D.\} and Ruchi Pandey and Haifang Zhang and Xiaofang Xie and Tang, \{Yi Wei\} and Kreiswirth, \{Barry N.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2016, American Society for Microbiology.",

year = "2016",

month = apr,

doi = "10.1128/AAC.03053-15",

language = "English",

volume = "60",

pages = "2519--2523",

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T1 - Genomic characterization of Enterobacter cloacae isolates from China that coproduce KPC-3 and NDM-1 carbapenemases

AU - Du, Hong

AU - Chen, Liang

AU - Chavda, Kalyan D.

AU - Pandey, Ruchi

AU - Zhang, Haifang

AU - Xie, Xiaofang

AU - Tang, Yi Wei

AU - Kreiswirth, Barry N.

PY - 2016/4

Y1 - 2016/4

N2 - Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The blaNDM-1-harboring plasmids carry IncA/C2 and IncR replicons, showing a mosaic plasmid structure, and the blaNDM-1 is harbored on a novel class I integron-like element. blaKPC-3 is located on a Tn3-ΔblaTEM-1-blaKPC-3-ΔTn1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.

AB - Here, we report two Enterobacter cloacae sequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. The blaNDM-1-harboring plasmids carry IncA/C2 and IncR replicons, showing a mosaic plasmid structure, and the blaNDM-1 is harbored on a novel class I integron-like element. blaKPC-3 is located on a Tn3-ΔblaTEM-1-blaKPC-3-ΔTn1722 element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.

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M3 - Article

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AN - SCOPUS:84963763908

SN - 0066-4804

VL - 60

SP - 2519

EP - 2523

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

ER -

Genomic characterization of Enterobacter cloacae isolates from China that coproduce KPC-3 and NDM-1 carbapenemases

Abstract

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