Genomic characterization of two KPC-producing Klebsiella isolates collected in 1997 in New York City

Brandon Eilertson; Liang Chen; Kalyan D. Chavda; Barry N. Kreiswirth

doi:10.1128/AAC.02458-16

Genomic characterization of two KPC-producing Klebsiella isolates collected in 1997 in New York City

Brandon Eilertson
, Liang Chen
, Kalyan D. Chavda
, Barry N. Kreiswirth

Center for Discovery and Innovation

SUNY Downstate Health Sciences University
Rutgers - The State University of New Jersey, Newark

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 bla_KPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and K. michiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the bla_KPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.

Original language	English
Article number	e02458-16
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02458-16
State	Published - Apr 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carbapenems
CRE
KPC
Tn4401b

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10.1128/AAC.02458-16

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title = "Genomic characterization of two KPC-producing Klebsiella isolates collected in 1997 in New York City",

abstract = "Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 blaKPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and K. michiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the blaKPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.",

keywords = "Carbapenems, CRE, KPC, Tn4401b",

author = "Brandon Eilertson and Liang Chen and Chavda, \{Kalyan D.\} and Kreiswirth, \{Barry N.\}",

year = "2017",

month = apr,

doi = "10.1128/AAC.02458-16",

language = "English",

volume = "61",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

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T1 - Genomic characterization of two KPC-producing Klebsiella isolates collected in 1997 in New York City

AU - Eilertson, Brandon

AU - Chen, Liang

AU - Chavda, Kalyan D.

AU - Kreiswirth, Barry N.

PY - 2017/4

Y1 - 2017/4

N2 - Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 blaKPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and K. michiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the blaKPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.

AB - Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 blaKPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and K. michiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the blaKPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids.

KW - Carbapenems

KW - CRE

KW - KPC

KW - Tn4401b

UR - https://www.scopus.com/pages/publications/85016818664

U2 - 10.1128/AAC.02458-16

DO - 10.1128/AAC.02458-16

M3 - Article

C2 - 28167551

AN - SCOPUS:85016818664

SN - 0066-4804

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

M1 - e02458-16

ER -

Genomic characterization of two KPC-producing Klebsiella isolates collected in 1997 in New York City

Abstract

UN SDGs

Keywords

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