Genomic characterization of VIM Metallo-β-Lactamase-Producing alcaligenes faecalis from Gaza, palestine

Nahed Al Laham; Kalyan D. Chavda; Astrid V. Cienfuegos-Gallet; Barry N. Kreiswirth; Liang Chen

doi:10.1128/AAC.01499-17

Genomic characterization of VIM Metallo-β-Lactamase-Producing alcaligenes faecalis from Gaza, palestine

Nahed Al Laham
, Kalyan D. Chavda
, Astrid V. Cienfuegos-Gallet
, Barry N. Kreiswirth
, Liang Chen

Al-Azhar University of Gaza
Rutgers - The State University of New Jersey, Newark
Universidad de Antioquia

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo--lactamase-producing Alcaligenes faecalis isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed bla_VIM-2 is harbored by a chromosomal genomic island among three strains, while bla_VIM-4 is carried by a novel plasmid in two strains.

Original language	English
Article number	e01499-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01499-17
State	Published - Nov 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alcaligenes faecalis
Genome
Metallo-β-lactamase
Palestine

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10.1128/AAC.01499-17

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title = "Genomic characterization of VIM Metallo-β-Lactamase-Producing alcaligenes faecalis from Gaza, palestine",

abstract = "Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo--lactamase-producing Alcaligenes faecalis isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed blaVIM-2 is harbored by a chromosomal genomic island among three strains, while blaVIM-4 is carried by a novel plasmid in two strains.",

keywords = "Alcaligenes faecalis, Genome, Metallo-β-lactamase, Palestine",

author = "Laham, \{Nahed Al\} and Chavda, \{Kalyan D.\} and Cienfuegos-Gallet, \{Astrid V.\} and Kreiswirth, \{Barry N.\} and Liang Chen",

year = "2017",

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doi = "10.1128/AAC.01499-17",

language = "English",

volume = "61",

journal = "Antimicrobial Agents and Chemotherapy",

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AU - Laham, Nahed Al

AU - Chavda, Kalyan D.

AU - Cienfuegos-Gallet, Astrid V.

AU - Kreiswirth, Barry N.

AU - Chen, Liang

PY - 2017/11

Y1 - 2017/11

N2 - Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo--lactamase-producing Alcaligenes faecalis isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed blaVIM-2 is harbored by a chromosomal genomic island among three strains, while blaVIM-4 is carried by a novel plasmid in two strains.

AB - Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo--lactamase-producing Alcaligenes faecalis isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed blaVIM-2 is harbored by a chromosomal genomic island among three strains, while blaVIM-4 is carried by a novel plasmid in two strains.

KW - Alcaligenes faecalis

KW - Genome

KW - Metallo-β-lactamase

KW - Palestine

UR - https://www.scopus.com/pages/publications/85032480991

U2 - 10.1128/AAC.01499-17

DO - 10.1128/AAC.01499-17

M3 - Article

C2 - 28848020

AN - SCOPUS:85032480991

SN - 0066-4804

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

M1 - e01499-17

ER -

Genomic characterization of VIM Metallo-β-Lactamase-Producing alcaligenes faecalis from Gaza, palestine

Abstract

UN SDGs

Keywords

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