TY - JOUR
T1 - Higher Risks of Toxicity and Incomplete Recovery in 13- to 17-Year-Old Females after Marrow Donation
T2 - RDSafe Peds Results
AU - Pulsipher, Michael A.
AU - Logan, Brent R.
AU - Kiefer, Deidre M.
AU - Chitphakdithai, Pintip
AU - Riches, Marcie L.
AU - Rizzo, J. Douglas
AU - Anderlini, Paolo
AU - Leitman, Susan F.
AU - Varni, James W.
AU - Kobusingye, Hati
AU - Besser, Rae Anne M.
AU - Miller, John P.
AU - Drexler, Rebecca J.
AU - Abdel-Mageed, Aly
AU - Ahmed, Ibrahim A.
AU - Ball, Edward D.
AU - Bolwell, Brian J.
AU - Bunin, Nancy J.
AU - Cheerva, Alexandra
AU - Delgado, David C.
AU - Dvorak, Christopher C.
AU - Gillio, Alfred P.
AU - Hahn, Theresa E.
AU - Hale, Gregory A.
AU - Haight, Ann E.
AU - Hayes-Lattin, Brandon M.
AU - Kasow, Kimberly A.
AU - Linenberger, Michael
AU - Magalhaes-Silverman, Margarida
AU - Mori, Shahram
AU - Prasad, Vinod K.
AU - Quigg, Troy C.
AU - Sahdev, Indira
AU - Schriber, Jeffrey R.
AU - Shenoy, Shalini
AU - Tse, William T.
AU - Yanik, Gregory A.
AU - Navarro, Willis H.
AU - Horowitz, Mary M.
AU - Confer, Dennis L.
AU - Shaw, Bronwen E.
AU - Switzer, Galen E.
N1 - Publisher Copyright:
© 2019
PY - 2019/5
Y1 - 2019/5
N2 - Although donation of bone marrow (BM)or peripheral blood stem cells (PBSCs)from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. To address this lack, we prospectively enrolled 294 donors age <18 years at 25 pediatric transplantation centers in North America, assessing them predonation, peridonation, and at 1 month, 6 months, and 1 year postdonation. We noted that 71% of children reported pain and 59% reported other symptoms peridonation, with resolution to 14% and 12% at 1 month postdonation. Both older age (age 13 to 17 years versus younger)and female sex were associated with higher levels of pain peridonation, with the highest rates in older females (57% with grade 2-4 pain and 17% with grade 3-4 pain). Multivariate analyses showed a 4-fold increase in risk for older females compared with males age <13 years (P <.001). At 1 year, 11% of 13- to 17-year-old females reported grade 2-4 pain, compared with 3% of males age 13 to 17 years, 0% of females age <13 years, and 1% of males age <13 years (P =.01). Males and females age 13 to 17 years failed to return to predonation pain levels at 1 year 22% and 23% of the time, respectively, compared with 3% and 10% in males and females age <13 years (P =.002). Our data show that females age 13 to 17 years are at increased risk of grade 2-4 pain at 1 year and >20% of females and males age 13 to 17 years do not return to baseline pain levels by 1 year after BM donation. Studies aimed at decreasing symptoms and improving recovery in older children are warranted.
AB - Although donation of bone marrow (BM)or peripheral blood stem cells (PBSCs)from children to family members undergoing allogeneic transplantation are well-established procedures, studies detailing levels of pain, symptoms, and long-term recovery are lacking. To address this lack, we prospectively enrolled 294 donors age <18 years at 25 pediatric transplantation centers in North America, assessing them predonation, peridonation, and at 1 month, 6 months, and 1 year postdonation. We noted that 71% of children reported pain and 59% reported other symptoms peridonation, with resolution to 14% and 12% at 1 month postdonation. Both older age (age 13 to 17 years versus younger)and female sex were associated with higher levels of pain peridonation, with the highest rates in older females (57% with grade 2-4 pain and 17% with grade 3-4 pain). Multivariate analyses showed a 4-fold increase in risk for older females compared with males age <13 years (P <.001). At 1 year, 11% of 13- to 17-year-old females reported grade 2-4 pain, compared with 3% of males age 13 to 17 years, 0% of females age <13 years, and 1% of males age <13 years (P =.01). Males and females age 13 to 17 years failed to return to predonation pain levels at 1 year 22% and 23% of the time, respectively, compared with 3% and 10% in males and females age <13 years (P =.002). Our data show that females age 13 to 17 years are at increased risk of grade 2-4 pain at 1 year and >20% of females and males age 13 to 17 years do not return to baseline pain levels by 1 year after BM donation. Studies aimed at decreasing symptoms and improving recovery in older children are warranted.
KW - BM collection toxicities
KW - Donor safety
KW - PBSC collection toxicities
KW - Stem cell transplantation
UR - https://www.scopus.com/pages/publications/85061429566
U2 - 10.1016/j.bbmt.2018.12.765
DO - 10.1016/j.bbmt.2018.12.765
M3 - Article
C2 - 30605731
AN - SCOPUS:85061429566
SN - 1083-8791
VL - 25
SP - 955
EP - 964
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 5
ER -