Importance of clonal complex 258 and IncFK2-like plasmids among a global collection of Klebsiella pneumoniae with blaKPC

Gisele Peirano; Patricia A. Bradford; Krystyna M. Kazmierczak; Liang Chen; Barry N. Kreiswirth; Johann D.D. Pitout

doi:10.1128/AAC.02610-16

Importance of clonal complex 258 and IncF_K2-like plasmids among a global collection of Klebsiella pneumoniae with bla_KPC

Gisele Peirano
, Patricia A. Bradford
, Krystyna M. Kazmierczak
, Liang Chen
, Barry N. Kreiswirth
, Johann D.D. Pitout

University of Calgary
Calgary Laboratory Services
AstraZeneca
International Health Management Associates, Inc.
Rutgers - The State University of New Jersey, Newark
University of Pretoria

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

This study was designed to determine the global distribution of clonal complex (CC) 258 and IncFII_K2-like plasmids with bla_KPC among 522 global Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates. CC258 (i.e., ST258 [clades I and II], ST11, ST340, and ST512) and ST147 were statistically associated with IncFII_K2-like KPC-containing plasmids and may possess an epidemiological advantage over isolates that harbored non-IncF KPC-harboring plasmids.

Original language	English
Article number	e02610
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	4
DOIs	https://doi.org/10.1128/AAC.02610-16
State	Published - Apr 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

IncF plasmids
Klebsiella pneumoniae
ST258

Access to Document

10.1128/AAC.02610-16

Cite this

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title = "Importance of clonal complex 258 and IncFK2-like plasmids among a global collection of Klebsiella pneumoniae with blaKPC",

abstract = "This study was designed to determine the global distribution of clonal complex (CC) 258 and IncFIIK2-like plasmids with blaKPC among 522 global Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates. CC258 (i.e., ST258 [clades I and II], ST11, ST340, and ST512) and ST147 were statistically associated with IncFIIK2-like KPC-containing plasmids and may possess an epidemiological advantage over isolates that harbored non-IncF KPC-harboring plasmids.",

keywords = "IncF plasmids, Klebsiella pneumoniae, ST258",

author = "Gisele Peirano and Bradford, \{Patricia A.\} and Kazmierczak, \{Krystyna M.\} and Liang Chen and Kreiswirth, \{Barry N.\} and Pitout, \{Johann D.D.\}",

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AU - Peirano, Gisele

AU - Bradford, Patricia A.

AU - Kazmierczak, Krystyna M.

AU - Chen, Liang

AU - Kreiswirth, Barry N.

AU - Pitout, Johann D.D.

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AB - This study was designed to determine the global distribution of clonal complex (CC) 258 and IncFIIK2-like plasmids with blaKPC among 522 global Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates. CC258 (i.e., ST258 [clades I and II], ST11, ST340, and ST512) and ST147 were statistically associated with IncFIIK2-like KPC-containing plasmids and may possess an epidemiological advantage over isolates that harbored non-IncF KPC-harboring plasmids.

KW - IncF plasmids

KW - Klebsiella pneumoniae

KW - ST258

UR - https://www.scopus.com/pages/publications/85016996872

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