In vitro activity of ceftriaxone and other cephalosporins against 602 clinical isolates of staphylococci from geographically diverse medical centers

M. A. Pfaller; A. L. Barry; L. D. Sabath; B. N. Kreiswirth; P. R. Murray; P. C. Fuchs; J. C. McLaughlin

doi:10.1007/BF00211442

In vitro activity of ceftriaxone and other cephalosporins against 602 clinical isolates of staphylococci from geographically diverse medical centers

M. A. Pfaller
, A. L. Barry
, L. D. Sabath
, B. N. Kreiswirth
, P. R. Murray
, P. C. Fuchs
, J. C. McLaughlin

Oregon Health and Science University
Clinical Microbiology Institute
University of Minnesota Twin Cities
Washington University St. Louis
Providence St. Vincent Medical Center
University of New Mexico

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The in vitro activity of ceftriaxone and six additional antimicrobial agents (ceftizoxime, cefoperazone, cefuroxime, fleroxacin, ciprofloxacin, and trimethoprim/sulfamethoxazole) was assessed or 602 recent clinical isolates of staphylococci from six geographically distinct medical centers in North America. All seven antimicrobial agents were active (90-100% of strains susceptible) against oxacillin-susceptible (OS) strains of Staphylococcus aureus (OSSA) and coagulase-negative staphylococci (OSCNS) but had limited activity against oxacillin resistant (OR) staphylococci. Our assessment of the in vitro antistaphylococcal activity of ceftriaxone against contemporary isolates of Staphylococcus aureus and coagulase-negative staphylococci indicates that the activity versus OS staphylococci has not changed over the past decade despite widespread use of the drug. It appears that these agents will continue to be useful for empiric therapy in those centers in which OR strains are uncommon.

Original language	English
Pages (from-to)	658-662
Number of pages	5
Journal	European Journal of Epidemiology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1007/BF00211442
State	Published - Nov 1993

Keywords

Ceftriaxone
Cephalosporins
Staphylococci

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10.1007/BF00211442

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@article{5a6d4ca96cd6448cbd4cc50c4f0c5468,

title = "In vitro activity of ceftriaxone and other cephalosporins against 602 clinical isolates of staphylococci from geographically diverse medical centers",

abstract = "The in vitro activity of ceftriaxone and six additional antimicrobial agents (ceftizoxime, cefoperazone, cefuroxime, fleroxacin, ciprofloxacin, and trimethoprim/sulfamethoxazole) was assessed or 602 recent clinical isolates of staphylococci from six geographically distinct medical centers in North America. All seven antimicrobial agents were active (90-100\% of strains susceptible) against oxacillin-susceptible (OS) strains of Staphylococcus aureus (OSSA) and coagulase-negative staphylococci (OSCNS) but had limited activity against oxacillin resistant (OR) staphylococci. Our assessment of the in vitro antistaphylococcal activity of ceftriaxone against contemporary isolates of Staphylococcus aureus and coagulase-negative staphylococci indicates that the activity versus OS staphylococci has not changed over the past decade despite widespread use of the drug. It appears that these agents will continue to be useful for empiric therapy in those centers in which OR strains are uncommon.",

keywords = "Ceftriaxone, Cephalosporins, Staphylococci",

author = "Pfaller, \{M. A.\} and Barry, \{A. L.\} and Sabath, \{L. D.\} and Kreiswirth, \{B. N.\} and Murray, \{P. R.\} and Fuchs, \{P. C.\} and McLaughlin, \{J. C.\}",

year = "1993",

month = nov,

doi = "10.1007/BF00211442",

language = "English",

volume = "9",

pages = "658--662",

journal = "European Journal of Epidemiology",

issn = "0392-2990",

publisher = "Springer Science and Business Media B.V.",

number = "6",

}

TY - JOUR

T1 - In vitro activity of ceftriaxone and other cephalosporins against 602 clinical isolates of staphylococci from geographically diverse medical centers

AU - Pfaller, M. A.

AU - Barry, A. L.

AU - Sabath, L. D.

AU - Kreiswirth, B. N.

AU - Murray, P. R.

AU - Fuchs, P. C.

AU - McLaughlin, J. C.

PY - 1993/11

Y1 - 1993/11

N2 - The in vitro activity of ceftriaxone and six additional antimicrobial agents (ceftizoxime, cefoperazone, cefuroxime, fleroxacin, ciprofloxacin, and trimethoprim/sulfamethoxazole) was assessed or 602 recent clinical isolates of staphylococci from six geographically distinct medical centers in North America. All seven antimicrobial agents were active (90-100% of strains susceptible) against oxacillin-susceptible (OS) strains of Staphylococcus aureus (OSSA) and coagulase-negative staphylococci (OSCNS) but had limited activity against oxacillin resistant (OR) staphylococci. Our assessment of the in vitro antistaphylococcal activity of ceftriaxone against contemporary isolates of Staphylococcus aureus and coagulase-negative staphylococci indicates that the activity versus OS staphylococci has not changed over the past decade despite widespread use of the drug. It appears that these agents will continue to be useful for empiric therapy in those centers in which OR strains are uncommon.

AB - The in vitro activity of ceftriaxone and six additional antimicrobial agents (ceftizoxime, cefoperazone, cefuroxime, fleroxacin, ciprofloxacin, and trimethoprim/sulfamethoxazole) was assessed or 602 recent clinical isolates of staphylococci from six geographically distinct medical centers in North America. All seven antimicrobial agents were active (90-100% of strains susceptible) against oxacillin-susceptible (OS) strains of Staphylococcus aureus (OSSA) and coagulase-negative staphylococci (OSCNS) but had limited activity against oxacillin resistant (OR) staphylococci. Our assessment of the in vitro antistaphylococcal activity of ceftriaxone against contemporary isolates of Staphylococcus aureus and coagulase-negative staphylococci indicates that the activity versus OS staphylococci has not changed over the past decade despite widespread use of the drug. It appears that these agents will continue to be useful for empiric therapy in those centers in which OR strains are uncommon.

KW - Ceftriaxone

KW - Cephalosporins

KW - Staphylococci

UR - https://www.scopus.com/pages/publications/0027762005

U2 - 10.1007/BF00211442

DO - 10.1007/BF00211442

M3 - Article

C2 - 8150070

AN - SCOPUS:0027762005

SN - 0392-2990

VL - 9

SP - 658

EP - 662

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

IS - 6

ER -

In vitro activity of ceftriaxone and other cephalosporins against 602 clinical isolates of staphylococci from geographically diverse medical centers

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Keywords

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