Interleukins: IL-7

W. J. Leonard; H. H. Xue

doi:10.1016/B0-12-370879-6/00478-6

Interleukins: IL-7

W. J. Leonard
, H. H. Xue

Center for Discovery and Innovation

National Institutes of Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Interleukin-7 (IL-7) is a stroma-derived cytokine that is indispensable for thymopoiesis in mice and humans. IL-7 also plays a pivotal role in the generation of memory CD4 ⁺ and CD8⁺ cells, and in controlling the numbers of naïve and memory T cells. Its combined effects of increasing thymic output and enhancing homeostatic expansion of T cells make IL-7 a potentially ideal agent to restore immune competence in patients with lymphopenia.

Original language	English
Title of host publication	Encyclopedia of Respiratory Medicine, Four-Volume Set
Publisher	Elsevier Inc.
Pages	365-368
Number of pages	4
ISBN (Print)	9780123708793
DOIs	https://doi.org/10.1016/B0-12-370879-6/00478-6
State	Published - 1 Jan 2006

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10.1016/B0-12-370879-6/00478-6

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abstract = "Interleukin-7 (IL-7) is a stroma-derived cytokine that is indispensable for thymopoiesis in mice and humans. IL-7 also plays a pivotal role in the generation of memory CD4 + and CD8+ cells, and in controlling the numbers of na{\"i}ve and memory T cells. Its combined effects of increasing thymic output and enhancing homeostatic expansion of T cells make IL-7 a potentially ideal agent to restore immune competence in patients with lymphopenia.",

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AB - Interleukin-7 (IL-7) is a stroma-derived cytokine that is indispensable for thymopoiesis in mice and humans. IL-7 also plays a pivotal role in the generation of memory CD4 + and CD8+ cells, and in controlling the numbers of naïve and memory T cells. Its combined effects of increasing thymic output and enhancing homeostatic expansion of T cells make IL-7 a potentially ideal agent to restore immune competence in patients with lymphopenia.

UR - https://www.scopus.com/pages/publications/85069287584

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DO - 10.1016/B0-12-370879-6/00478-6

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BT - Encyclopedia of Respiratory Medicine, Four-Volume Set

PB - Elsevier Inc.

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Interleukins: IL-7

Abstract

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