Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review

Vandan D. Upadhyaya; Steven Douedi; Brandon Garcia; Jimmy Gonzalez; Ndausung Udongwo; Juanqin Wei; Qiang Nai; Arif Asif; Shuvendu Sen

doi:10.14740/jocmr4387

Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review

Vandan D. Upadhyaya
, Steven Douedi
, Brandon Garcia
, Jimmy Gonzalez
, Ndausung Udongwo
, Juanqin Wei
, Qiang Nai
, Arif Asif
, Shuvendu Sen

School of Medicine

Jersey Shore University Medical Center
Rutgers - The State University of New Jersey, New Brunswick
Robert Wood Johnson University Hospital
Cooley Dickinson Hospital

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss β-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment.

Original language	English
Pages (from-to)	753-757
Number of pages	5
Journal	Journal of Clinical Medicine Research
Volume	12
Issue number	12
DOIs	https://doi.org/10.14740/jocmr4387
State	Published - 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Beta-adrenergic pathway
Beta-blockers
Cancer
Pancreatic adenocarcinoma

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10.14740/jocmr4387

Cite this

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title = "Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review",

abstract = "Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss β-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment.",

keywords = "Beta-adrenergic pathway, Beta-blockers, Cancer, Pancreatic adenocarcinoma",

author = "Upadhyaya, \{Vandan D.\} and Steven Douedi and Brandon Garcia and Jimmy Gonzalez and Ndausung Udongwo and Juanqin Wei and Qiang Nai and Arif Asif and Shuvendu Sen",

note = "Publisher Copyright: {\textcopyright} The authors",

year = "2020",

doi = "10.14740/jocmr4387",

language = "English",

volume = "12",

pages = "753--757",

journal = "Journal of Clinical Medicine Research",

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TY - JOUR

T1 - Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma

T2 - A Literature Review

AU - Upadhyaya, Vandan D.

AU - Douedi, Steven

AU - Garcia, Brandon

AU - Gonzalez, Jimmy

AU - Udongwo, Ndausung

AU - Wei, Juanqin

AU - Nai, Qiang

AU - Asif, Arif

AU - Sen, Shuvendu

PY - 2020

Y1 - 2020

N2 - Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss β-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment.

AB - Pancreatic adenocarcinoma has a poor 5-year survival rate despite many advancements in pharmacotherapies. Studies have suggested the involvement of β-adrenergic pathway in the progression of pancreatic adenocarcinoma. Animal experiments and retrospective trials have reported the use of beta-blockers as potential chemo-preventative agents. This review aims to discuss β-adrenergic physiology as it relates to the progression of pancreatic adenocarcinoma and review outcomes on the use of beta-blockers for its treatment.

KW - Beta-adrenergic pathway

KW - Beta-blockers

KW - Cancer

KW - Pancreatic adenocarcinoma

UR - https://www.scopus.com/pages/publications/85140804813

U2 - 10.14740/jocmr4387

DO - 10.14740/jocmr4387

M3 - Review article

AN - SCOPUS:85140804813

SN - 1918-3003

VL - 12

SP - 753

EP - 757

JO - Journal of Clinical Medicine Research

JF - Journal of Clinical Medicine Research

IS - 12

ER -

Mechanism and Effect of Beta-Blockers on Pancreatic Adenocarcinoma: A Literature Review

Abstract

UN SDGs

Keywords

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