Molecular Epidemiology of Mycobacterium tuberculosis in a South African Community with High HIV Prevalence

Keren Middelkoop; Linda Gail Bekker; Barun Mathema; Elena Shashkina; Natalia Kurepina; Andrew Whitelaw; Dorothy Fallows; Carl Morrow; Barry Kreiswirth; Gilla Kaplan; Robin Wood

doi:10.1086/605930

Molecular Epidemiology of Mycobacterium tuberculosis in a South African Community with High HIV Prevalence

Keren Middelkoop
, Linda Gail Bekker
, Barun Mathema
, Elena Shashkina
, Natalia Kurepina
, Andrew Whitelaw
, Dorothy Fallows
, Carl Morrow
, Barry Kreiswirth
, Gilla Kaplan
, Robin Wood

Desmond Tutu Health Foundation
Public Health Research Institute, New York
University of Cape Town
National Health Laboratory Services
Rutgers - The State University of New Jersey, New Brunswick

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

To explore the relationship between human immunodeficiency virus (HIV) and Mycobacterium tuberculosis genotypes, we performed IS6110-based restriction fragmentlength polymorphism analysis on M. tuberculosis culture specimens from patients with smear-positive tuberculosis in a periurban community in South Africa from 2001 through 2005. Among 151 isolates, 95 strains were identified within 26 families, with 54% clustering. HIV status was associated with W-Beijing strains (P = .009) but not with clustering per se. The high frequency of clustering suggests ongoing transmission in both HIV-negative and HIV-positive individuals in this community. The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control.

Original language	English
Pages (from-to)	1207-1211
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	200
Issue number	8
DOIs	https://doi.org/10.1086/605930
State	Published - 15 Oct 2009

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10.1086/605930

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abstract = "To explore the relationship between human immunodeficiency virus (HIV) and Mycobacterium tuberculosis genotypes, we performed IS6110-based restriction fragmentlength polymorphism analysis on M. tuberculosis culture specimens from patients with smear-positive tuberculosis in a periurban community in South Africa from 2001 through 2005. Among 151 isolates, 95 strains were identified within 26 families, with 54\% clustering. HIV status was associated with W-Beijing strains (P = .009) but not with clustering per se. The high frequency of clustering suggests ongoing transmission in both HIV-negative and HIV-positive individuals in this community. The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control.",

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AU - Bekker, Linda Gail

AU - Mathema, Barun

AU - Shashkina, Elena

AU - Kurepina, Natalia

AU - Whitelaw, Andrew

AU - Fallows, Dorothy

AU - Morrow, Carl

AU - Kreiswirth, Barry

AU - Kaplan, Gilla

AU - Wood, Robin

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AB - To explore the relationship between human immunodeficiency virus (HIV) and Mycobacterium tuberculosis genotypes, we performed IS6110-based restriction fragmentlength polymorphism analysis on M. tuberculosis culture specimens from patients with smear-positive tuberculosis in a periurban community in South Africa from 2001 through 2005. Among 151 isolates, 95 strains were identified within 26 families, with 54% clustering. HIV status was associated with W-Beijing strains (P = .009) but not with clustering per se. The high frequency of clustering suggests ongoing transmission in both HIV-negative and HIV-positive individuals in this community. The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control.

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ER -

Molecular Epidemiology of Mycobacterium tuberculosis in a South African Community with High HIV Prevalence

Abstract

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