Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

Yixiong Heng; Peck Gee Seah; Jie Yee Siew; Hui Chien Tay; Amit Singhal; Vanessa Mathys; Mehdi Kiass; Pablo Bifani; Véronique Dartois; Maxime Hervé

doi:10.1016/j.tube.2011.05.003

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

Yixiong Heng
, Peck Gee Seah
, Jie Yee Siew
, Hui Chien Tay
, Amit Singhal
, Vanessa Mathys
, Mehdi Kiass
, Pablo Bifani
, Véronique Dartois
, Maxime Hervé

Center for Discovery and Innovation

Novartis
Agency for Science, Technology and Research, Singapore
Scientific Institute of Public Health, Brussels

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.

Original language	English
Pages (from-to)	339-341
Number of pages	3
Journal	Tuberculosis
Volume	91
Issue number	4
DOIs	https://doi.org/10.1016/j.tube.2011.05.003
State	Published - Jul 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Histopathology
Hypoxia
Pimonidazole
Rat
Tuberculosis

Access to Document

10.1016/j.tube.2011.05.003

Cite this

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title = "Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat",

abstract = "Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.",

keywords = "Histopathology, Hypoxia, Pimonidazole, Rat, Tuberculosis",

author = "Yixiong Heng and Seah, \{Peck Gee\} and Siew, \{Jie Yee\} and Tay, \{Hui Chien\} and Amit Singhal and Vanessa Mathys and Mehdi Kiass and Pablo Bifani and V{\'e}ronique Dartois and Maxime Herv{\'e}",

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volume = "91",

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T1 - Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

AU - Heng, Yixiong

AU - Seah, Peck Gee

AU - Siew, Jie Yee

AU - Tay, Hui Chien

AU - Singhal, Amit

AU - Mathys, Vanessa

AU - Kiass, Mehdi

AU - Bifani, Pablo

AU - Dartois, Véronique

AU - Hervé, Maxime

PY - 2011/7

Y1 - 2011/7

N2 - Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.

AB - Hypoxia is believed to influence the metabolic state of Mycobacterium tuberculosis and cause phenotypic drug resistance. Using pimonidazole adduct staining, we show that lung lesions of infected rats contain regions of low oxygen tension. Our results support the use of the rat model for evaluating anaerobic drug activity in vivo.

KW - Histopathology

KW - Hypoxia

KW - Pimonidazole

KW - Rat

KW - Tuberculosis

UR - https://www.scopus.com/pages/publications/79960229277

U2 - 10.1016/j.tube.2011.05.003

DO - 10.1016/j.tube.2011.05.003

M3 - Article

C2 - 21636324

AN - SCOPUS:79960229277

SN - 1472-9792

VL - 91

SP - 339

EP - 341

JO - Tuberculosis

JF - Tuberculosis

IS - 4

ER -

Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat

Abstract

UN SDGs

Keywords

Access to Document

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