NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains

Bernice J. Klotoe; Natalia Kurepina; Elena Zholdibayeva; S. Panaiotov; Barry N. Kreiswirth; Richard Anthony; Christophe Sola; Guislaine Refrégier

doi:10.1016/j.tube.2019.101894

NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains

Bernice J. Klotoe
, Natalia Kurepina
, Elena Zholdibayeva
, S. Panaiotov
, Barry N. Kreiswirth
, Richard Anthony
, Christophe Sola
, Guislaine Refrégier

Commissariat à l’énergie atomique et aux énergies alternatives
National Center for Biotechnology
National Center of Infectious and Parasitic Diseases Bulgaria
National Institute of Public Health and the Environment

Research output: Contribution to journal › Article › peer-review

Abstract

The most widely discussed antibiotic-resistant tuberculosis strains (“W” and “B0/W148”, “CAO”) belong to L2/Beijing Lineage and are characterized by IS6110 insertion sequences at the NTF locus. We present a high-throughput, microbead-based method, called NTF-RINT for detection of IS in NTF and Rifampicin and Isoniazid Typing. This method provides tuberculosis diagnostic confirmation, screens for the so-called modern L2/Beijing sublineage and detects mutations involved in resistance to Rifampicin (RIF) and Isoniazid (INH).

Original language	English
Article number	101894
Journal	Tuberculosis
Volume	120
DOIs	https://doi.org/10.1016/j.tube.2019.101894
State	Published - Jan 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Atypical Beijing
MDR-TB
Molecular epidemiology
Typical Beijing

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10.1016/j.tube.2019.101894

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title = "NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains",

abstract = "The most widely discussed antibiotic-resistant tuberculosis strains ({\textquotedblleft}W{\textquotedblright} and {\textquotedblleft}B0/W148{\textquotedblright}, {\textquotedblleft}CAO{\textquotedblright}) belong to L2/Beijing Lineage and are characterized by IS6110 insertion sequences at the NTF locus. We present a high-throughput, microbead-based method, called NTF-RINT for detection of IS in NTF and Rifampicin and Isoniazid Typing. This method provides tuberculosis diagnostic confirmation, screens for the so-called modern L2/Beijing sublineage and detects mutations involved in resistance to Rifampicin (RIF) and Isoniazid (INH).",

keywords = "Atypical Beijing, MDR-TB, Molecular epidemiology, Typical Beijing",

author = "Klotoe, \{Bernice J.\} and Natalia Kurepina and Elena Zholdibayeva and S. Panaiotov and Kreiswirth, \{Barry N.\} and Richard Anthony and Christophe Sola and Guislaine Refr{\'e}gier",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2020",

month = jan,

doi = "10.1016/j.tube.2019.101894",

language = "English",

volume = "120",

journal = "Tuberculosis",

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T1 - NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains

AU - Klotoe, Bernice J.

AU - Kurepina, Natalia

AU - Zholdibayeva, Elena

AU - Panaiotov, S.

AU - Kreiswirth, Barry N.

AU - Anthony, Richard

AU - Sola, Christophe

AU - Refrégier, Guislaine

PY - 2020/1

Y1 - 2020/1

N2 - The most widely discussed antibiotic-resistant tuberculosis strains (“W” and “B0/W148”, “CAO”) belong to L2/Beijing Lineage and are characterized by IS6110 insertion sequences at the NTF locus. We present a high-throughput, microbead-based method, called NTF-RINT for detection of IS in NTF and Rifampicin and Isoniazid Typing. This method provides tuberculosis diagnostic confirmation, screens for the so-called modern L2/Beijing sublineage and detects mutations involved in resistance to Rifampicin (RIF) and Isoniazid (INH).

AB - The most widely discussed antibiotic-resistant tuberculosis strains (“W” and “B0/W148”, “CAO”) belong to L2/Beijing Lineage and are characterized by IS6110 insertion sequences at the NTF locus. We present a high-throughput, microbead-based method, called NTF-RINT for detection of IS in NTF and Rifampicin and Isoniazid Typing. This method provides tuberculosis diagnostic confirmation, screens for the so-called modern L2/Beijing sublineage and detects mutations involved in resistance to Rifampicin (RIF) and Isoniazid (INH).

KW - Atypical Beijing

KW - MDR-TB

KW - Molecular epidemiology

KW - Typical Beijing

UR - https://www.scopus.com/pages/publications/85076632274

U2 - 10.1016/j.tube.2019.101894

DO - 10.1016/j.tube.2019.101894

M3 - Article

C2 - 32090855

AN - SCOPUS:85076632274

SN - 1472-9792

VL - 120

JO - Tuberculosis

JF - Tuberculosis

M1 - 101894

ER -

NTF-RINT, a new method for the epidemiological surveillance of MDR Mycobacterium tuberculosis L2/Beijing strains

Abstract

UN SDGs

Keywords

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