Oxygen depletion-induced dormancy in Mycobacterium bovis BCG

Amanda Lim; Marianne Eleuterio; Bernd Hutter; Bernadette Murugasu-Oei; Thomas Dick

doi:10.1128/jb.181.7.2252-2256.1999

Oxygen depletion-induced dormancy in Mycobacterium bovis BCG

Amanda Lim
, Marianne Eleuterio
, Bernd Hutter
, Bernadette Murugasu-Oei
, Thomas Dick

Center for Discovery and Innovation

Agency for Science, Technology and Research, Singapore

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and α-crystallin-like protein and is sensitive to metronidazole.

Original language	English
Pages (from-to)	2252-2256
Number of pages	5
Journal	Journal of Bacteriology
Volume	181
Issue number	7
DOIs	https://doi.org/10.1128/jb.181.7.2252-2256.1999
State	Published - Apr 1999

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10.1128/jb.181.7.2252-2256.1999

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title = "Oxygen depletion-induced dormancy in Mycobacterium bovis BCG",

abstract = "Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and α-crystallin-like protein and is sensitive to metronidazole.",

author = "Amanda Lim and Marianne Eleuterio and Bernd Hutter and Bernadette Murugasu-Oei and Thomas Dick",

year = "1999",

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T1 - Oxygen depletion-induced dormancy in Mycobacterium bovis BCG

AU - Lim, Amanda

AU - Eleuterio, Marianne

AU - Hutter, Bernd

AU - Murugasu-Oei, Bernadette

AU - Dick, Thomas

PY - 1999/4

Y1 - 1999/4

N2 - Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and α-crystallin-like protein and is sensitive to metronidazole.

AB - Gradual depletion of oxygen causes the shift-down of aerobic growing Mycobacterium bovis BCG to an anaerobic synchronized state of nonreplicating persistence. The persistent culture shows induction of glycine dehydrogenase and α-crystallin-like protein and is sensitive to metronidazole.

UR - https://www.scopus.com/pages/publications/0032911198

U2 - 10.1128/jb.181.7.2252-2256.1999

DO - 10.1128/jb.181.7.2252-2256.1999

M3 - Article

C2 - 10094705

AN - SCOPUS:0032911198

SN - 0021-9193

VL - 181

SP - 2252

EP - 2256

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 7

ER -

Oxygen depletion-induced dormancy in Mycobacterium bovis BCG

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