Paneth Cell Multipotency Induced by Notch Activation following Injury

Shiyan Yu; Kevin Tong; Yanlin Zhao; Iyshwarya Balasubramanian; George S. Yap; Ronaldo P. Ferraris; Edward M. Bonder; Michael P. Verzi; Nan Gao

doi:10.1016/j.stem.2018.05.002

Paneth Cell Multipotency Induced by Notch Activation following Injury

Shiyan Yu
, Kevin Tong
, Yanlin Zhao
, Iyshwarya Balasubramanian
, George S. Yap
, Ronaldo P. Ferraris
, Edward M. Bonder
, Michael P. Verzi
, Nan Gao

Center for Discovery and Innovation

Rutgers - The State University of New Jersey, Newark
Rutgers - The State University of New Jersey, New Brunswick
RBHS-NEW JERSEY MEDICAL SCHOOL

Research output: Contribution to journal › Article › peer-review

247 Scopus citations

Abstract

Using a knockin allele engineered at the mouse Lyz1 locus, Yu et al. report that irradiation induces a subset of Paneth cells to dedifferentiate. This process can also be induced by expressing active Notch1 in this cell type. The study documents Paneth cell plasticity, expanding current understanding of intestinal regeneration.

Original language	English
Pages (from-to)	46-59.e5
Journal	Cell Stem Cell
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2018.05.002
State	Published - 5 Jul 2018

Keywords

Lyz1
Notch
Paneth cell
RNA-seq
Wnt
intestinal stem cell
lysozyme
plasticity

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10.1016/j.stem.2018.05.002

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title = "Paneth Cell Multipotency Induced by Notch Activation following Injury",

abstract = "Using a knockin allele engineered at the mouse Lyz1 locus, Yu et al. report that irradiation induces a subset of Paneth cells to dedifferentiate. This process can also be induced by expressing active Notch1 in this cell type. The study documents Paneth cell plasticity, expanding current understanding of intestinal regeneration.",

keywords = "Lyz1, Notch, Paneth cell, RNA-seq, Wnt, intestinal stem cell, lysozyme, plasticity",

author = "Shiyan Yu and Kevin Tong and Yanlin Zhao and Iyshwarya Balasubramanian and Yap, \{George S.\} and Ferraris, \{Ronaldo P.\} and Bonder, \{Edward M.\} and Verzi, \{Michael P.\} and Nan Gao",

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T1 - Paneth Cell Multipotency Induced by Notch Activation following Injury

AU - Yu, Shiyan

AU - Tong, Kevin

AU - Zhao, Yanlin

AU - Balasubramanian, Iyshwarya

AU - Yap, George S.

AU - Ferraris, Ronaldo P.

AU - Bonder, Edward M.

AU - Verzi, Michael P.

AU - Gao, Nan

PY - 2018/7/5

Y1 - 2018/7/5

N2 - Using a knockin allele engineered at the mouse Lyz1 locus, Yu et al. report that irradiation induces a subset of Paneth cells to dedifferentiate. This process can also be induced by expressing active Notch1 in this cell type. The study documents Paneth cell plasticity, expanding current understanding of intestinal regeneration.

AB - Using a knockin allele engineered at the mouse Lyz1 locus, Yu et al. report that irradiation induces a subset of Paneth cells to dedifferentiate. This process can also be induced by expressing active Notch1 in this cell type. The study documents Paneth cell plasticity, expanding current understanding of intestinal regeneration.

KW - Lyz1

KW - Notch

KW - Paneth cell

KW - RNA-seq

KW - Wnt

KW - intestinal stem cell

KW - lysozyme

KW - plasticity

UR - https://www.scopus.com/pages/publications/85047308026

U2 - 10.1016/j.stem.2018.05.002

DO - 10.1016/j.stem.2018.05.002

M3 - Article

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AN - SCOPUS:85047308026

SN - 1934-5909

VL - 23

SP - 46-59.e5

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 1

ER -

Paneth Cell Multipotency Induced by Notch Activation following Injury

Abstract

Keywords

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