Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

Diana P. Callender; Nalini Jayaprakash; Aaron Bell; Vidmantas Petraitis; Ruta Petratienes; Myrna Candelario; Robert Schaufele; James M. Dunn; Shizuko Sei; Thomas J. Walsh; Frank M. Balis

doi:10.1128/aac.43.4.972

Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

Diana P. Callender
, Nalini Jayaprakash
, Aaron Bell
, Vidmantas Petraitis
, Ruta Petratienes
, Myrna Candelario
, Robert Schaufele
, James M. Dunn
, Shizuko Sei
, Thomas J. Walsh
, Frank M. Balis

Center for Discovery and Innovation

National Institutes of Health
Verex Laboratories, Inc.
SAIC

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.

Original language	English
Pages (from-to)	972-974
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	43
Issue number	4
DOIs	https://doi.org/10.1128/aac.43.4.972
State	Published - Apr 1999

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1128/aac.43.4.972

Cite this

@article{a2ab917bb71441e089a37c7ebb32e61c,

title = "Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits",

abstract = "The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76\%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.",

author = "Callender, \{Diana P.\} and Nalini Jayaprakash and Aaron Bell and Vidmantas Petraitis and Ruta Petratienes and Myrna Candelario and Robert Schaufele and Dunn, \{James M.\} and Shizuko Sei and Walsh, \{Thomas J.\} and Balis, \{Frank M.\}",

year = "1999",

month = apr,

doi = "10.1128/aac.43.4.972",

language = "English",

volume = "43",

pages = "972--974",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "4",

}

TY - JOUR

T1 - Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

AU - Callender, Diana P.

AU - Jayaprakash, Nalini

AU - Bell, Aaron

AU - Petraitis, Vidmantas

AU - Petratienes, Ruta

AU - Candelario, Myrna

AU - Schaufele, Robert

AU - Dunn, James M.

AU - Sei, Shizuko

AU - Walsh, Thomas J.

AU - Balis, Frank M.

PY - 1999/4

Y1 - 1999/4

N2 - The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.

AB - The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.

UR - https://www.scopus.com/pages/publications/0032949509

U2 - 10.1128/aac.43.4.972

DO - 10.1128/aac.43.4.972

M3 - Article

C2 - 10103214

AN - SCOPUS:0032949509

SN - 0066-4804

VL - 43

SP - 972

EP - 974

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 4

ER -

Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this