Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals

Barun Mathema; Emily Cross; Erica Dun; Steven Park; Jane Bedell; Brenda Slade; Martha Williams; Lee Riley; Vishnu Chaturvedi; David S. Perlin

doi:10.1086/322600

Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals

Barun Mathema
, Emily Cross
, Erica Dun
, Steven Park
, Jane Bedell
, Brenda Slade
, Martha Williams
, Lee Riley
, Vishnu Chaturvedi
, David S. Perlin

Center for Discovery and Innovation

Public Health Research Institute, New York
Columbia University
Cornell University
University of California at Berkeley
Wadsworth Center for Laboratories and Research

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

We enrolled 382 college-age women in a cross-sectional survey to investigate the relationship between use of over-the-counter (OTC) azole-based antifungal drugs and vaginal colonization by drug-resistant Candida. This study showed no correlation (P=.506) between previous OTC exposure and colonization of drug-resistant Candida in vaginal flora. However, a small number of resistant Candida species isolates were obtained from women with a history of multiple exposures to OTC antifungals; given the widespread use of these products, this may be an emerging concern.

Original language	English
Pages (from-to)	E23-27
Journal	Clinical Infectious Diseases
Volume	33
Issue number	5
DOIs	https://doi.org/10.1086/322600
State	Published - 1 Sep 2001

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SDG 3 Good Health and Well-being

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10.1086/322600

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title = "Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals",

abstract = "We enrolled 382 college-age women in a cross-sectional survey to investigate the relationship between use of over-the-counter (OTC) azole-based antifungal drugs and vaginal colonization by drug-resistant Candida. This study showed no correlation (P=.506) between previous OTC exposure and colonization of drug-resistant Candida in vaginal flora. However, a small number of resistant Candida species isolates were obtained from women with a history of multiple exposures to OTC antifungals; given the widespread use of these products, this may be an emerging concern.",

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AU - Mathema, Barun

AU - Cross, Emily

AU - Dun, Erica

AU - Park, Steven

AU - Bedell, Jane

AU - Slade, Brenda

AU - Williams, Martha

AU - Riley, Lee

AU - Chaturvedi, Vishnu

AU - Perlin, David S.

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AB - We enrolled 382 college-age women in a cross-sectional survey to investigate the relationship between use of over-the-counter (OTC) azole-based antifungal drugs and vaginal colonization by drug-resistant Candida. This study showed no correlation (P=.506) between previous OTC exposure and colonization of drug-resistant Candida in vaginal flora. However, a small number of resistant Candida species isolates were obtained from women with a history of multiple exposures to OTC antifungals; given the widespread use of these products, this may be an emerging concern.

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JF - Clinical Infectious Diseases

IS - 5

ER -

Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals

Abstract

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