SKN7 of Candida albicans: Mutant Construction and Phenotype Analysis

Praveen Singh; Neeraj Chauhan; Anup Ghosh; Freddie Dixon; Richard Calderone

doi:10.1128/IAI.72.4.2390-2394.2004

SKN7 of Candida albicans: Mutant Construction and Phenotype Analysis

Praveen Singh
, Neeraj Chauhan
, Anup Ghosh
, Freddie Dixon
, Richard Calderone

Center for Discovery and Innovation

Georgetown University
University of the District of Columbia

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H₂0 ₂ in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssklp response regulators of C. albicans is discussed.

Original language	English
Pages (from-to)	2390-2394
Number of pages	5
Journal	Infection and Immunity
Volume	72
Issue number	4
DOIs	https://doi.org/10.1128/IAI.72.4.2390-2394.2004
State	Published - Apr 2004

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SDG 3 Good Health and Well-being

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10.1128/IAI.72.4.2390-2394.2004

Cite this

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abstract = "The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10\% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H20 2 in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssklp response regulators of C. albicans is discussed.",

author = "Praveen Singh and Neeraj Chauhan and Anup Ghosh and Freddie Dixon and Richard Calderone",

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AU - Singh, Praveen

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AU - Ghosh, Anup

AU - Dixon, Freddie

AU - Calderone, Richard

PY - 2004/4

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AB - The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H20 2 in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssklp response regulators of C. albicans is discussed.

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M3 - Article

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ER -

SKN7 of Candida albicans: Mutant Construction and Phenotype Analysis

Abstract

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