Staphylococcus aureus YoeB homologues inhibit translation initiation

Satoshi Yoshizumi; Yonglong Zhang; Yoshihiro Yamaguchi; Liang Chen; Barry N. Kreiswirth; Masayori Inouye

doi:10.1128/JB.00623-09

Staphylococcus aureus YoeB homologues inhibit translation initiation

Satoshi Yoshizumi
, Yonglong Zhang
, Yoshihiro Yamaguchi
, Liang Chen
, Barry N. Kreiswirth
, Masayori Inouye

Center for Discovery and Innovation

Rutgers - The State University of New Jersey, New Brunswick
Public Health Research Institute, New York

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin system found in various bacterial genomes. Here, we show that Staphylococcus aureus contains two YoeB homologues, both of which function as ribosome-dependent mRNA interferases to inhibit translation initiation in a manner identical to that of YoeB-ec from Escherichia coli.

Original language	English
Pages (from-to)	5868-5872
Number of pages	5
Journal	Journal of Bacteriology
Volume	191
Issue number	18
DOIs	https://doi.org/10.1128/JB.00623-09
State	Published - Sep 2009

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10.1128/JB.00623-09

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title = "Staphylococcus aureus YoeB homologues inhibit translation initiation",

abstract = "YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin system found in various bacterial genomes. Here, we show that Staphylococcus aureus contains two YoeB homologues, both of which function as ribosome-dependent mRNA interferases to inhibit translation initiation in a manner identical to that of YoeB-ec from Escherichia coli.",

author = "Satoshi Yoshizumi and Yonglong Zhang and Yoshihiro Yamaguchi and Liang Chen and Kreiswirth, \{Barry N.\} and Masayori Inouye",

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AU - Yoshizumi, Satoshi

AU - Zhang, Yonglong

AU - Yamaguchi, Yoshihiro

AU - Chen, Liang

AU - Kreiswirth, Barry N.

AU - Inouye, Masayori

PY - 2009/9

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N2 - YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin system found in various bacterial genomes. Here, we show that Staphylococcus aureus contains two YoeB homologues, both of which function as ribosome-dependent mRNA interferases to inhibit translation initiation in a manner identical to that of YoeB-ec from Escherichia coli.

AB - YoeB is a bacterial toxin encoded by the yefM-yoeB toxin-antitoxin system found in various bacterial genomes. Here, we show that Staphylococcus aureus contains two YoeB homologues, both of which function as ribosome-dependent mRNA interferases to inhibit translation initiation in a manner identical to that of YoeB-ec from Escherichia coli.

UR - https://www.scopus.com/pages/publications/69949087541

U2 - 10.1128/JB.00623-09

DO - 10.1128/JB.00623-09

M3 - Article

C2 - 19581360

AN - SCOPUS:69949087541

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VL - 191

SP - 5868

EP - 5872

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 18

ER -

Staphylococcus aureus YoeB homologues inhibit translation initiation

Abstract

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