The importance of animal models in tuberculosis vaccine development

Armando Acosta; Norazmi Mohd Nor; Rogelio Hernandez-Panda; Nadine Alvarez; Reinier Borrero; Juan F. Infante; Maria E. Sarmieto

The importance of animal models in tuberculosis vaccine development

Armando Acosta
, Norazmi Mohd Nor
, Rogelio Hernandez-Panda
, Nadine Alvarez
, Reinier Borrero
, Juan F. Infante
, Maria E. Sarmieto

Center for Discovery and Innovation

Instituto Finlay
Universiti Sains Malaysia
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

The research, development, and production of vaccines are still highly dependent on the use of animal models in the different evaluation steps. Despite this fact, there are a strong interest and ongoing efforts to reduce the use of animals in vaccine production. Tuberculosis vaccine development is one important example of the complexities related with the use of animal models for the production of new vaccines. This review summarises some of the general aspects related with the use of animals in vaccine research and production, achievements and challenges towards the goal of the rational use of animals, particularly in the case of tuberculosis vaccine development.

Original language	English
Pages (from-to)	5-11
Number of pages	7
Journal	Malaysian Journal of Medical Sciences
Volume	18
Issue number	4
State	Published - Oct 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animal models
Animal testing alternatives
Research and development
Tuberculosis
Vaccines

Cite this

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title = "The importance of animal models in tuberculosis vaccine development",

abstract = "The research, development, and production of vaccines are still highly dependent on the use of animal models in the different evaluation steps. Despite this fact, there are a strong interest and ongoing efforts to reduce the use of animals in vaccine production. Tuberculosis vaccine development is one important example of the complexities related with the use of animal models for the production of new vaccines. This review summarises some of the general aspects related with the use of animals in vaccine research and production, achievements and challenges towards the goal of the rational use of animals, particularly in the case of tuberculosis vaccine development.",

keywords = "Animal models, Animal testing alternatives, Research and development, Tuberculosis, Vaccines",

author = "Armando Acosta and Nor, \{Norazmi Mohd\} and Rogelio Hernandez-Panda and Nadine Alvarez and Reinier Borrero and Infante, \{Juan F.\} and Sarmieto, \{Maria E.\}",

year = "2011",

month = oct,

language = "English",

volume = "18",

pages = "5--11",

journal = "Malaysian Journal of Medical Sciences",

issn = "1394-195X",

publisher = "Penerbit Universiti Sains Malaysia",

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}

TY - JOUR

T1 - The importance of animal models in tuberculosis vaccine development

AU - Acosta, Armando

AU - Nor, Norazmi Mohd

AU - Hernandez-Panda, Rogelio

AU - Alvarez, Nadine

AU - Borrero, Reinier

AU - Infante, Juan F.

AU - Sarmieto, Maria E.

PY - 2011/10

Y1 - 2011/10

N2 - The research, development, and production of vaccines are still highly dependent on the use of animal models in the different evaluation steps. Despite this fact, there are a strong interest and ongoing efforts to reduce the use of animals in vaccine production. Tuberculosis vaccine development is one important example of the complexities related with the use of animal models for the production of new vaccines. This review summarises some of the general aspects related with the use of animals in vaccine research and production, achievements and challenges towards the goal of the rational use of animals, particularly in the case of tuberculosis vaccine development.

AB - The research, development, and production of vaccines are still highly dependent on the use of animal models in the different evaluation steps. Despite this fact, there are a strong interest and ongoing efforts to reduce the use of animals in vaccine production. Tuberculosis vaccine development is one important example of the complexities related with the use of animal models for the production of new vaccines. This review summarises some of the general aspects related with the use of animals in vaccine research and production, achievements and challenges towards the goal of the rational use of animals, particularly in the case of tuberculosis vaccine development.

KW - Animal models

KW - Animal testing alternatives

KW - Research and development

KW - Tuberculosis

KW - Vaccines

UR - https://www.scopus.com/pages/publications/80053557224

M3 - Review article

AN - SCOPUS:80053557224

SN - 1394-195X

VL - 18

SP - 5

EP - 11

JO - Malaysian Journal of Medical Sciences

JF - Malaysian Journal of Medical Sciences

IS - 4

ER -

The importance of animal models in tuberculosis vaccine development

Abstract

UN SDGs

Keywords

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