The role of action potential alternans in the initiation of atrial fibrillation in humans: A review and future directions

Michael R. Franz; Sameer M. Jamal; Sanjiv M. Narayan

doi:10.1093/europace/eus273

The role of action potential alternans in the initiation of atrial fibrillation in humans: A review and future directions

Michael R. Franz
, Sameer M. Jamal
, Sanjiv M. Narayan

School of Medicine

VA Medical Center
University of California at San Diego

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation.

Original language	English
Pages (from-to)	v58-v64
Journal	Europace
Volume	14
Issue number	SUPPL. 5
DOIs	https://doi.org/10.1093/europace/eus273
State	Published - Nov 2012

Keywords

Action potential duration (APD)
Action potential duration (APD) alternans
Alternans
Atrial fibrillation
Electrical heterogeneity
Electrical remodelling
Electrical restitution curve (ERC)
Monophasic action potential (MAP)
Rate maladaptation

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10.1093/europace/eus273

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title = "The role of action potential alternans in the initiation of atrial fibrillation in humans: A review and future directions",

abstract = "This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation.",

keywords = "Action potential duration (APD), Action potential duration (APD) alternans, Alternans, Atrial fibrillation, Electrical heterogeneity, Electrical remodelling, Electrical restitution curve (ERC), Monophasic action potential (MAP), Rate maladaptation",

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year = "2012",

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AU - Narayan, Sanjiv M.

PY - 2012/11

Y1 - 2012/11

N2 - This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation.

AB - This review highlights the role of atrial monophasic action potential duration (APD) in understanding atrial electrical properties in paroxysmal, persistent, and permanent atrial fibrillation (AF) states. Alternans of APD and rate maladaptation in a spatially divergent way appear mechanistically involved in AF initiation, development, and persistence. The underlying pathophysiology warrants further investigation.

KW - Action potential duration (APD)

KW - Action potential duration (APD) alternans

KW - Alternans

KW - Atrial fibrillation

KW - Electrical heterogeneity

KW - Electrical remodelling

KW - Electrical restitution curve (ERC)

KW - Monophasic action potential (MAP)

KW - Rate maladaptation

UR - https://www.scopus.com/pages/publications/84868521636

U2 - 10.1093/europace/eus273

DO - 10.1093/europace/eus273

M3 - Review article

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AN - SCOPUS:84868521636

SN - 1099-5129

VL - 14

SP - v58-v64

JO - Europace

JF - Europace

IS - SUPPL. 5

ER -

The role of action potential alternans in the initiation of atrial fibrillation in humans: A review and future directions

Abstract

Keywords

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